[人类细小病毒B19感染与儿童特发性血小板减少性紫癜的相关性：中文文献的Meta分析]
[Association of human parvovirus B19 infection and childhood idiopathic thrombocytopenic purpura: a meta analysis of Chinese literatures].
作者信息
Zhang Yao-Dong, Hu Qun, Liu Shuang-You, Liu Ai-Guo, Wang Guan-Ling, Xiong Hao, Sun Yan
机构信息
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2009 Dec;11(12):999-1001.
OBJECTIVE
To study the relationship between human parvovirus B19 infection and childhood idiopathic thrombocytopenic purpura (ITP) by the principle of evidence based medicine.
METHODS
Papers related to the relationship between human parvovirus B19 infection and childhood ITP published between 1994 and 2008 were retrieved electronically from the Chinese Journals Full-text Database and the Wanfang Data. These relevant papers on case-control trials were statistically studied by meta analysis.
RESULTS
Eight papers that met the inclusion criteria were included for this meta analysis. Five hundred and sixteen cases of childhood ITP and 246 healthy controls were enrolled. The meta analysis showed that the incidence of human parvovirus B19 infection in the ITP group was significantly higher than that in the control group (OR=13.71, 95% CI=7.07-26.59, Z=7.75, p<0.01).
CONCLUSIONS
Human parvovirus B19 infection is closely associated with childhood ITP.
目的
采用循证医学原理研究人类细小病毒B19感染与儿童特发性血小板减少性紫癜（ITP）之间的关系。
方法
通过中国期刊全文数据库和万方数据，以电子方式检索1994年至2008年间发表的有关人类细小病毒B19感染与儿童ITP关系的论文。对这些有关病例对照试验的相关论文进行Meta分析统计研究。
结果
本Meta分析纳入了8篇符合纳入标准的论文。共纳入516例儿童ITP病例和246例健康对照。Meta分析显示，ITP组中人类细小病毒B19感染的发生率显著高于对照组（OR=13.71，95%CI=7.07-26.59，Z=7.75，p<0.01）。
结论
人类细小病毒B19感染与儿童ITP密切相关。
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