Mahmoudian Touran, Modaresi Mohamadreza, Zarei Ali, Poursafa Parinaz, Kelishadi Roya
Department of Pediatric Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan.
Zhongguo Dang Dai Er Ke Za Zhi. 2009 Nov;11(11):873-6.
Lead poisoning is a potentially devastating problem among young children. Chronic low level lead exposure can lead to learning disabilities and behavior changes such as colic, insomnia, hyperactivity, impaired growth, hearing loss and upper extremity weakness. The purpose of this cross sectional study was to determine the blood lead level in children with neurological disorders in comparison with healthy controls.
Blood lead concentrations were measured by flame atomic absorption spectrometry in 100 children aged 1-10 years and suffering from various neurological disorders. One hundred age and sex-matched healthy children served as controls.
The mean blood lead concentration was higher in children with neurological disorders than in controls (113.2 + or - 47.5 microg/L vs 84.7 + or - 38.0 microg/L; p<0.01). Overall, 44% of children with neurological disorders and 19% of controls were found to have increased blood lead levels, i.e.>100 microg/L.
An increase in blood lead level in children might be related to neurological disorders. The measurement of blood lead level might be included in diagnostic eveluation of children with neurological disorders.
铅中毒在幼儿中是一个潜在的严重问题。长期低水平铅暴露可导致学习障碍和行为改变，如腹绞痛、失眠、多动、生长发育受损、听力丧失和上肢无力。本横断面研究的目的是确定患有神经系统疾病的儿童与健康对照儿童的血铅水平。
采用火焰原子吸收光谱法测定100名1至10岁患有各种神经系统疾病儿童的血铅浓度。100名年龄和性别匹配的健康儿童作为对照。
患有神经系统疾病的儿童平均血铅浓度高于对照组（113.2±47.5微克/升对84.7±38.0微克/升；p<0.01）。总体而言，44%患有神经系统疾病的儿童和19%的对照儿童血铅水平升高，即>100微克/升。
儿童血铅水平升高可能与神经系统疾病有关。血铅水平的检测可能应纳入患有神经系统疾病儿童的诊断评估中。
