Bansal Neha, Aggarwal Anju, Faridi M M A, Sharma Tusha, Baneerjee B D
Department of Pediatrics.
Department of Biochemistry University College of Medical Sciences, Guru Tegh Bahadur Hospital, New Delhi, India.
Glob Pediatr Health. 2017 Mar 30;4:2333794X17696681. doi: 10.1177/2333794X17696681. eCollection 2017.
Cerebral palsy is a common motor disability in childhood. Raised lead levels affect cognition. Children with cerebral palsy may have raised lead levels, further impairing their residual cognitive motor and behavioral abilities. Environmental exposure and abnormal eating habits may lead to increased lead levels. To measure blood lead levels in children with cerebral palsy and compare them with healthy neurologically normal children. To correlate blood lead levels with environmental factors. : Prospective case-control study. : Tertiary care hospital. : Cases comprised 34 children with cerebral palsy, and controls comprised 34 neurologically normal, age- and sex-matched children. : Clinical and demographic details were recorded as per proforma. Detailed environmental history was recorded to know the source of exposure to lead. These children were investigated and treated as per protocol. Venous blood was collected in ethylenediaminetetraacetic acid vials for analysis of blood lead levels. Lead levels were estimated by Schimadzu Flame AA-6800 (atomic absorption spectrophotometer). Data were analyzed using SPSS version 17. < .05 was taken as significant. Mean blood lead levels were 9.20 ± 8.31 µg/dL in cerebral palsy cases and 2.89 ± 3.04 µg/dL in their controls ( < .001). Among children with cerebral palsy, 19 (55.88%) children had blood lead levels ≥5 µg/dL. Lead levels in children with pica were 12.33 ± 10.02 µg/dL in comparison to children with no history of pica, 6.70 ± 4.60 µg/dL ( = .029). No correlation was found between hemoglobin and blood lead levels in cases and controls. In our study, blood lead levels are raised in children with cerebral palsy. However, further studies are required to show effects of raised levels in these children.
脑瘫是儿童期常见的运动障碍。铅水平升高会影响认知。脑瘫儿童的铅水平可能会升高，从而进一步损害其残余的认知、运动和行为能力。环境暴露和异常饮食习惯可能导致铅水平升高。测量脑瘫儿童的血铅水平，并与神经功能正常的健康儿童进行比较。将血铅水平与环境因素进行关联。：前瞻性病例对照研究。：三级护理医院。：病例组包括34名脑瘫儿童，对照组包括34名年龄和性别匹配、神经功能正常的儿童。：按照表格记录临床和人口统计学细节。记录详细的环境史以了解铅暴露源。这些儿童按照方案进行调查和治疗。采集静脉血于乙二胺四乙酸瓶中用于分析血铅水平。采用岛津火焰原子吸收光谱仪AA - 6800测定铅水平。使用SPSS 17版软件进行数据分析。P <.05被视为具有统计学意义。脑瘫病例组的平均血铅水平为9.20±8.31µg/dL，对照组为2.89±3.04µg/dL（P <.001）。在脑瘫儿童中，19名（55.88%）儿童的血铅水平≥5µg/dL。有异食癖的儿童铅水平为12.33±10.02µg/dL，而无该病史的儿童为6.70±4.60µg/dL（P = 0.029）。病例组和对照组中血红蛋白与血铅水平之间未发现相关性。在我们的研究中，脑瘫儿童的血铅水平升高。然而，需要进一步研究以表明这些儿童血铅水平升高的影响。
