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Otic preparations altered permeability and thickness of the round window membrane of the chinchilla.

作者信息

Ikeda K, Morizono T, Takasaka T

机构信息

Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

ORL J Otorhinolaryngol Relat Spec. 1991;53(2):91-3. doi: 10.1159/000276195.

DOI:10.1159/000276195
PMID:2011381
Abstract

The effects of topical otic preparations (Cortisporin, Coly-Mycin, Aristocort, and Bestron) upon the permeability of the round window membrane (RWM) in chinchillas were investigated. Using K(+)-selective microelectrodes, the concentration of tetraethylammonium (TEA) ions was measured. Changes in the thickness of the RWM were measured using light microscopy. The RWM permeability was reduced significantly in Cortisporin- and Coly-Mycin-treated ears. Moreover, these two drugs resulted in a marked thickening of the RWM. In contrast, Aristocort or Bestron resulted in no alteration of the RWM permeability.

摘要

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