Ikeda K, Morizono T
Department of Otolaryngology, University of Minnesota Medical School, Minneapolis.
Arch Otolaryngol Head Neck Surg. 1988 Aug;114(8):895-7. doi: 10.1001/archotol.1988.01860200079023.
The effects of endotoxin, exotoxin, and otitis media on the permeability of the round window membrane (RWM) in chinchillas was investigated by detecting tetraethylammonium chloride, applied to the RWM, using a potassium-selective microelectrode in the scala tympani. The RWM, 48 hours following the application of endotoxin or exotoxin, became significantly more permeable to tetraethylammonium chloride than the normal RWM. Two weeks after the obstruction of the eustachian tube, the permeability of the RWM was decreased. These results suggest that bacterial toxins and the consequential migration of chemical inflammatory mediators act as promotive factors of RWM permeability, and that a pathologic thickness of the RWM and the presence of effusion induced by the obstruction of the eustachian tube acts as an inhibitory factor. In the clinical role of RWM permeability in human otitis media, these two factors must be taken into consideration.
通过在鼓阶中使用钾选择性微电极检测应用于圆窗膜（RWM）的四乙铵氯化物，研究了内毒素、外毒素和中耳炎对龙猫圆窗膜通透性的影响。在内毒素或外毒素应用48小时后，RWM对四乙铵氯化物的通透性比正常RWM显著增加。咽鼓管阻塞两周后，RWM的通透性降低。这些结果表明，细菌毒素和化学炎症介质的相应迁移是RWM通透性的促进因素，而RWM的病理厚度和咽鼓管阻塞引起的积液的存在是抑制因素。在人类中耳炎中RWM通透性的临床作用方面，必须考虑这两个因素。
