Bodolay E, Bacskó G, Bezsilla E, Szegedi G
Debreceni Orvostudományi Egyetem, III. sz. Belgyógyászati Klinika.
Orv Hetil. 1991 Mar 24;132(12):619-22.
The authors carried out a retrospective study of the pregnancy of 31 women suffering from mixed connective tissue disease (MCTD). They summed up the number of growing children, stillborns, and spontaneous abortion in the period before and after commencement of the disease process. Their results point to a rather marked occurrence of spontaneous abortion even in the period before the actual disease process. In the majority of patients there were observable clinical signs which, retrospectively, was an autoimmune disease process, but now known as the appearance of MCTD. In the period following the disease only a smaller percentage of patients became pregnant, not on account of their age or previous spontaneous abortions, but rather because of their symptoms. They investigated those clinical abnormalities which could be reasons for the adverse conditions for fetal development in MCTD.
作者对31例混合性结缔组织病（MCTD）患者的妊娠情况进行了回顾性研究。他们总结了疾病进程开始前后的活产儿、死产儿及自然流产数量。结果表明，即使在实际疾病进程开始前，自然流产的发生率也相当高。大多数患者存在可观察到的临床体征，回顾来看，这是一种自身免疫性疾病进程，现称为MCTD的表现。疾病发生后的时期内，只有较小比例的患者怀孕，这并非由于年龄或既往自然流产，而是因为其症状。他们研究了那些可能导致MCTD胎儿发育不良情况的临床异常。
