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Malignant transformation of an untreated congenital sacrococcygeal teratoma: a amplification at 8q and 12p detected by comparative genomic hybridization.

作者信息

Golas Mariola Monika, Gunawan Bastian, Raab Björn-Werner, Füzesi László, Lange Bettina

出版信息

Cancer Genet Cytogenet. 2010 Feb;197(1):95-8. doi: 10.1016/j.cancergencyto.2009.10.013.

DOI:10.1016/j.cancergencyto.2009.10.013
PMID:20113846
Abstract
摘要

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Interphase fluorescence in situ hybridization analysis of chromosome 12p abnormalities is useful for distinguishing epidermoid cysts of the testis from pure mature teratoma.12号染色体短臂异常的间期荧光原位杂交分析有助于鉴别睾丸表皮样囊肿与单纯成熟畸胎瘤。
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High-resolution comparative genomic hybridization detects extra chromosome arm 12p material in most cases of carcinoma in situ adjacent to overt germ cell tumors, but not before the invasive tumor development.高分辨率比较基因组杂交在大多数紧邻明显生殖细胞肿瘤的原位癌病例中检测到额外的12号染色体短臂物质，但在侵袭性肿瘤发生之前未检测到。
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Expression pattern of clinically relevant markers in paediatric germ cell- and sex-cord stromal tumours is similar to adult testicular tumours.儿科生殖细胞和性索间质肿瘤中临床相关标志物的表达模式与成人睾丸肿瘤相似。
Virchows Arch. 2014 Nov;465(5):567-77. doi: 10.1007/s00428-014-1635-1. Epub 2014 Jul 30.
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RecQL4 helicase amplification is involved in human breast tumorigenesis.RecQL4 解旋酶扩增参与人类乳腺癌发生。
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