Cui Shengjie, Han Jing, Khandakar Binny, Friedman Barak, Nunez Domingo, Sara Gabriel A, Levi Gabriel S
The Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029, USA.
Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY10029, USA.
Case Rep Pathol. 2021 Nov 27;2021:5045250. doi: 10.1155/2021/5045250. eCollection 2021.
Sacrococcygeal teratomas (SCT) are most commonly seen in infants and children but are rare in adults. Most adult SCT are benign and mature with a minority of tumors having immature components or overt malignancy. Here, we report a 65-year-old female with a SCT developing adenocarcinoma. The patient was diagnosed with benign sacrococcygeal cystic teratoma on her initial hospital visit and was treated with surgical resection. She was followed up postoperatively and was noted to have a markedly elevated CA 19-9 level 13 months after the surgery. Radiological and clinical examination revealed thickening of the perirectal soft tissues, located near the inferior portion of her previous incision site. Histological evaluation of the lesion showed invasive, moderately differentiated adenocarcinoma. Immunohistochemical staining results were suggestive, but not diagnostic, of anal gland adenocarcinoma. This case report expands the knowledge regarding an adenocarcinoma arising from a previously benign, adult SCT.
骶尾部畸胎瘤（SCT）在婴幼儿中最为常见，但在成人中罕见。大多数成人SCT是良性且成熟的，少数肿瘤含有不成熟成分或明显恶性。在此，我们报告一名65岁女性，其骶尾部畸胎瘤发生了腺癌。该患者初次就诊时被诊断为良性骶尾部囊性畸胎瘤，并接受了手术切除治疗。术后对她进行了随访，术后13个月发现其CA 19-9水平显著升高。影像学和临床检查显示，在她先前手术切口部位下方附近的直肠周围软组织增厚。病变的组织学评估显示为浸润性、中度分化腺癌。免疫组化染色结果提示为肛门腺腺癌，但不能确诊。本病例报告扩展了关于先前良性成人SCT发生腺癌的认识。
