血友病的研究进展：实验研究与治疗

Advances in hemophilia: experimental aspects and therapy.

机构信息

Division of Pediatrics, Hematology Section, The University of Texas Health Science Center, 6411 Fannin, Houston, TX 77030, USA.

出版信息

Hematol Oncol Clin North Am. 2010 Feb;24(1):181-98. doi: 10.1016/j.hoc.2009.11.003.

DOI:10.1016/j.hoc.2009.11.003

PMID:20113902

Abstract

This article describes recent clinical and research advances in hemophilia therapy. Different prophylactic regimens for the management of severe hemophilia are described along with the use of adjuvant treatment options to achieve hemostasis. The safety and efficacy of radionuclide synovectomy with phosphorus 32-sulfur colloid to treat existing joint arthropathy also are described. The development of inhibitors to factor VIII or IX remains a challenge for hemophilia care and recent approaches to achieve immune tolerance induction are discussed. Finally, recent advances in hemophilia are mentioned, including the role of iron, inflammation, and angiogenesis in the pathogenesis of hemophilic arthropathy.

摘要

本文介绍了血友病治疗方面的最新临床和研究进展。文中介绍了不同的预防性治疗方案，以管理重度血友病，并讨论了辅助治疗方案在实现止血方面的应用。此外，文中还描述了放射性核素滑膜切除术联合磷 32-硫磺胶体治疗关节病变的安全性和有效性。因子 VIII 或因子 IX 抑制剂的开发仍然是血友病治疗的一个挑战，文中还讨论了最近实现免疫耐受诱导的方法。最后，本文还提到了血友病的最新进展，包括铁、炎症和血管生成在血友病性关节病发病机制中的作用。