Department of Psychiatry, Medical School, University of Ioannina, Ioannina 45110, Greece.
Gen Hosp Psychiatry. 2010 Jan-Feb;32(1):57-65. doi: 10.1016/j.genhosppsych.2009.09.002. Epub 2009 Oct 1.
Crohn's disease (CD) is associated with smoking, while ulcerative colitis (UC) is largely a disease of nonsmokers. We aimed to test whether the smoking-linked personality characteristic "impulsive sensation seeking" (ImpSS) is correlated to the differences in smoking in inflammatory bowel disease (IBD).
In 185 IBD patients, the General Health Questionnaire and the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ) were administered. The Fagerstrom Test for Nicotine Dependence was used to assess smokers' nicotine dependence.
CD patients were twice as likely to be active smokers than UC patients. CD patients presented higher ImpSS scores than UC patients, but the differences became nonsignificant after adjustment for age, gender, education and psychological distress. Multivariate analyses, however, showed that the relationship of ImpSS with current smoking was stronger in CD patients. Moderator analysis showed that the relationship of ImpSS with nicotine dependence was also greater in smokers with CD than in those with UC. No other ZKPQ subscale was correlated to disease type, current smoking or nicotine dependence.
ImpSS is associated with current smoking and nicotine dependence in IBD, and these associations are stronger in CD. These findings might be relevant to more effective interventions aiming at smoking cessation in CD patients.
克罗恩病（CD）与吸烟有关，而溃疡性结肠炎（UC）主要发生在不吸烟者中。我们旨在测试与吸烟相关的人格特征“冲动寻求感觉”（ImpSS）是否与炎症性肠病（IBD）中吸烟的差异有关。
在 185 名 IBD 患者中，进行了一般健康问卷和 Zuckerman-Kuhlman 人格问卷（ZKPQ）的评估。使用 Fagerstrom 尼古丁依赖测试来评估吸烟者的尼古丁依赖程度。
CD 患者的吸烟率是 UC 患者的两倍。与 UC 患者相比，CD 患者的 ImpSS 评分更高，但在调整年龄、性别、教育和心理困扰后，差异不再显著。然而，多变量分析表明，ImpSS 与当前吸烟的关系在 CD 患者中更强。调节分析显示，在 CD 患者中，ImpSS 与尼古丁依赖的关系也比 UC 患者更强。其他 ZKPQ 子量表与疾病类型、当前吸烟或尼古丁依赖无关。
ImpSS 与 IBD 中的当前吸烟和尼古丁依赖有关，在 CD 中这些关联更强。这些发现可能与旨在帮助 CD 患者戒烟的更有效的干预措施有关。
