Barrett S M, Standen P J, Lee A S, Hawkey C J, Logan R F
Department of Psychiatry, University Hospital, Nottingham, UK.
Eur J Gastroenterol Hepatol. 1996 Jul;8(7):651-5.
To assess whether psychological factors distinguished patients with Crohn's disease (CD) from those with ulcerative colitis (UC).
Survey of prevalent inflammatory bowel disease patients (n = 82) attending a gastroenterology clinic.
Administration of three self-report rating scales, the Eysenck Personality Questionnaire, the General Health Questionnaire and the Hospital Anxiety and Depression scale.
CD patients were significantly more extroverted (P = 0.04) than UC patients, tended to have higher psychoticism scores (P = 0.06) but similar neuroticism scores. Extroversion and psychoticism scores were weakly associated with smoking status. In logistic regression models that adjusted for age, sex and smoking the associations with extroversion and psychoticism scores persisted but were no longer significant at the 5% level. In the final model the psychoticism score was more important than the extroversion score.
These results suggest that there are substantial personality differences between patients with CD and UC. Although some of the differences in this study were associated with smoking, adjusting for smoking reduced, but did not abolish, the associations with personality scores.
评估心理因素能否区分克罗恩病（CD）患者与溃疡性结肠炎（UC）患者。
对一家胃肠病诊所中82名炎症性肠病患者进行调查。
使用三种自我报告评定量表，即艾森克人格问卷、一般健康问卷和医院焦虑抑郁量表。
CD患者比UC患者明显更外向（P = 0.04），精神病性得分往往更高（P = 0.06），但神经质得分相似。外向性和精神病性得分与吸烟状况弱相关。在调整了年龄、性别和吸烟因素的逻辑回归模型中，与外向性和精神病性得分的关联仍然存在，但在5%水平上不再显著。在最终模型中，精神病性得分比外向性得分更重要。
这些结果表明，CD患者和UC患者之间存在显著的人格差异。尽管本研究中的一些差异与吸烟有关，但调整吸烟因素后，与人格得分的关联有所减少，但并未消除。
