Gergely L, Czeglédy J, Szalka A, Váczi L, Binder L
Acta Microbiol Acad Sci Hung. 1977;24(1):13-9.
A method has been evolved for the demonstration of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection in 83 cases of infectious mononucleosis. Serum samples were tested for EBV IgM, anti-VCA IgG, anti-EBNA, CMV IgM and CMV IgG antibodies. An acute-phase sample (or samples) and a convalescence sample were examined in each case, and in 44 cases an additional samples was examined 5-12 months after the illness. Since the different antibodies showed characteristic differences in both titre and persistence, a reliable serodiagnosis has become possible. Acute EBV infection is characterized by the presence of EBV-VCA IgG and EBV IgG antibodies and the lack of anti-EBNA. The latter becomes demonstrable as late as the 4th to 5th month after infection. Mean age of the patients was 19 years. EBV infection was demonstrated in 65%, CMV infection in 18% of the cases. In 12% double infection seemed to be probable.
已开发出一种方法，用于检测83例传染性单核细胞增多症患者的爱泼斯坦-巴尔病毒（EBV）和巨细胞病毒（CMV）感染情况。检测血清样本中的EBV IgM、抗VCA IgG、抗EBNA、CMV IgM和CMV IgG抗体。对每例患者检测急性期样本（一个或多个）和恢复期样本，44例患者在发病5至12个月后还检测了额外样本。由于不同抗体在滴度和持续时间上表现出特征性差异，因此可靠的血清学诊断成为可能。急性EBV感染的特征是存在EBV-VCA IgG和EBV IgG抗体且缺乏抗EBNA。后者在感染后第4至5个月才会显现。患者的平均年龄为19岁。65%的病例检测出EBV感染，18%的病例检测出CMV感染。12%的病例似乎可能为双重感染。
