Division of Gastroenterology and Digestive Endoscopy, "Madonna del Soccorso" Hospital, San Benedetto del Tronto (AP), Italy.
Dig Liver Dis. 2010 Aug;42(8):549-53. doi: 10.1016/j.dld.2010.01.001. Epub 2010 Jan 29.
Standardization of the (13)C-octanoic acid breath test is still lacking.
To evaluate the accuracy of the (13)C-octanoic acid breath test using a new standardized ready-to-eat, gluten-, glucose-, and lactose-free muffin.
Healthy subjects were recruited and sorted by sex and age. Patients with diabetic gastroparesis and untreated celiac disease with known gastric motility disorders were also tested with the new labelled muffin. Expired breath (13)CO(2) was analysed and t(1/2) was calculated.
Overall, 131 healthy subjects were enrolled. The reference range of t(1/2) was 88+/-29min with the value of 146min as the upper limit of normal range. No significant difference in t(1/2) was found among subjects sorted by sex or age. The within-subject variability of t(1/2) was 17%. Mean (+/-standard deviation) t(1/2) values were 179+/-50min in patients with diabetic gastroparesis (n=8) and 151+/-20min in those with untreated celiac disease (n=11) (p<or=0.001 vs controls).
A new standardized test meal simplifies the execution of the (13)C-octanoic acid breath test, is not influenced by sex or age, has low intra-individual variability, is palatable, does not cause side effects, and is able to evaluate gastric emptying in both patients and healthy controls. Moreover, it can be used in subjects with lactose intolerance, diabetes, and celiac disease.
（13）C-辛酸呼气试验的标准化仍有待完善。
评估一种新型标准化即食、无麸质、无葡萄糖、无乳糖松饼在（13）C-辛酸呼气试验中的准确性。
招募健康受试者，并按性别和年龄进行分类。还对患有糖尿病胃轻瘫和未经治疗的乳糜泻伴有已知胃动力障碍的患者进行了新标记的松饼试验。分析呼气（13）CO2，并计算 t1/2。
共纳入 131 名健康受试者。t1/2 的参考范围为 88+/-29min，146min 为正常范围上限。按性别或年龄分类的受试者 t1/2 无显著差异。t1/2 的个体内变异性为 17%。8 例糖尿病胃轻瘫患者（n=8）和 11 例未经治疗的乳糜泻患者（n=11）的 t1/2 平均值（+/-标准差）分别为 179+/-50min 和 151+/-20min（p<or=0.001 与对照组相比）。
新型标准化试验餐简化了（13）C-辛酸呼气试验的执行过程，不受性别或年龄影响，个体内变异性低，口感良好，无副作用，能够评估患者和健康对照者的胃排空情况。此外，它还可用于乳糖不耐受、糖尿病和乳糜泻患者。
