Cappello G, Malatesta M G, Ferri A, Ciccaglione A F, Toracchio S, Grossi L, Marzio L
Gastroenterology Unit, G. D'Annunzio University, Chieti-Pescara, Italy.
Am J Gastroenterol. 2000 Nov;95(11):3097-100. doi: 10.1111/j.1572-0241.2000.03255.x.
The 13C octanoic acid breath test (OBT) has been proposed as a reliable noninvasive test to measure gastric emptying. OBT has been compared with scintigraphy; however, there are no data comparing it with gastric emptying measured with real-time ultrasonography (RUS) The aim of the study was to correlate gastric emptying of a solid-liquid meal, with OBT and RUS simultaneously evaluated in a group of normal volunteers.
A total of 14 normal subjects ingested a standard test meal (one scrambled egg with two slices of white bread, 10 g of butter, and 300 ml of tap water). The egg yolk was mixed with 0.1 ml of 13C octanoic acid. Breath samples for 13CO2 analysis were collected in breath bags and were analyzed by means of isotope-selective nondispersive infrared spectrometry (IRIS). RUS was simultaneously performed by calculating the antral area following a previous validated method. Breath samples and antral area were taken at baseline and every 15 min after the meal during the first 2 h and every 30 min for another 2 h. Lag time (Tlag) and gastric half emptying time (T(1/2)) were calculated for OBT and RUS. Data were analyzed by the Student's t test for paired data, correlation coefficient, and regression line.
The results show a statistically significant longer Tlag and T(1/2) for OBT in comparison with RUS (p < 0.001). A significant correlation and positive regression line was computed between OBT and RUS for Tlag and for T(1/2).
Our results show that OBT overestimates gastric emptying parameters of a solid-liquid meal in comparison with RUS. However, both techniques give data in good correlation. Because OBT is less operator-dependent than RUS, it may be useful in comparative gastric emptying studies.
13C辛酸呼气试验（OBT）已被提议作为一种可靠的非侵入性检测方法来测量胃排空。OBT已与闪烁扫描法进行了比较；然而，尚无将其与实时超声（RUS）测量的胃排空进行比较的数据。本研究的目的是在一组正常志愿者中同时评估固体-液体餐的胃排空与OBT和RUS的相关性。
共有14名正常受试者摄入标准试验餐（一个炒鸡蛋、两片白面包、10克黄油和300毫升自来水）。将蛋黄与0.1毫升13C辛酸混合。用于13CO2分析的呼气样本收集在呼气袋中，并通过同位素选择性非分散红外光谱法（IRIS）进行分析。RUS通过采用先前验证的方法计算胃窦面积同时进行。在基线时以及进食后的前2小时内每15分钟采集一次呼气样本和胃窦面积，之后的另外2小时内每30分钟采集一次。计算OBT和RUS的延迟时间（Tlag）和胃半排空时间（T(1/2)）。数据采用配对数据的Student's t检验、相关系数和回归线进行分析。
结果显示，与RUS相比，OBT的Tlag和T(1/2)在统计学上显著更长（p < 0.001）。计算得出OBT和RUS的Tlag和T(1/2)之间存在显著相关性和正回归线。
我们的结果表明，与RUS相比，OBT高估了固体-液体餐的胃排空参数。然而，两种技术得出的数据相关性良好。由于OBT比RUS对操作者的依赖性更小，它可能在比较胃排空研究中有用。
