Center for Plant and Food Science, College of Health and Science, University of Western Sydney, Penrith South DC, NSW, Australia.
Nutr Res. 2010 Jan;30(1):49-56. doi: 10.1016/j.nutres.2009.12.003.
Agaricus bisporus (white button mushroom; WBM) contains high levels of dietary fibers and antioxidants including vitamin C, D, and B(12); folates; and polyphenols that may provide beneficial effects on cardiovascular and diabetic diseases. The objective of this study was to examine the hypothesis that intake of the fruiting bodies of WBM regulates anticholesterolemic and antiglycemic responses in rats fed a hypercholesterolemic diet (0.5% cholesterol; 14% fat) and rats with type 2 diabetes induced by injection of streptozotocin (STZ) (50 mg/kg body weight), respectively. The STZ-induced diabetic male Sprague-Dawley rats fed the Agaricus bisporus powder (ABP; 200 mg/kg of body weight) for 3 weeks had significantly reduced plasma glucose and triglyceride (TG) concentrations (24.7% and 39.1%, respectively), liver enzyme activities, alanine aminotransferase and aspartate aminotransferase (11.7% and 15.7%, respectively), and liver weight gain (P < .05). In hypercholesterolemic rats, oral feeding of ABP for 4 weeks resulted in a significant decrease in plasma total cholesterol (TC) and low-density lipoprotein (LDL) (22.8% and 33.1%, respectively) (P < .05). A similar significant decrease in hepatic cholesterol and TG concentrations was observed (36.2% and 20.8%, respectively) (P < .05). Decrease in TC, LDL, and TG concentrations was accompanied by a significant increase in plasma high-density lipoprotein concentrations. It was concluded that A bisporus mushroom had both hypoglycemic and hypolipidemic activity in rats.
双孢蘑菇（白蘑菇；WBM）含有高水平的膳食纤维和抗氧化剂，包括维生素 C、D 和 B(12)；叶酸；和多酚，可能对心血管疾病和糖尿病有有益的影响。本研究的目的是检验以下假设，即食用 WBM 的子实体可分别调节高胆固醇饮食（0.5%胆固醇；14%脂肪）喂养的大鼠和注射链脲佐菌素（STZ）（50mg/kg 体重）诱导的 2 型糖尿病大鼠的抗胆固醇和降血糖反应。STZ 诱导的糖尿病雄性 Sprague-Dawley 大鼠喂食双孢蘑菇粉（ABP；200mg/kg 体重）3 周，血浆葡萄糖和甘油三酯（TG）浓度显著降低（分别为 24.7%和 39.1%），肝酶活性，丙氨酸氨基转移酶和天冬氨酸氨基转移酶（分别为 11.7%和 15.7%），以及肝重增加（P<0.05）。在高胆固醇血症大鼠中，ABP 口服喂养 4 周可显著降低血浆总胆固醇（TC）和低密度脂蛋白（LDL）（分别为 22.8%和 33.1%）（P<0.05）。肝胆固醇和 TG 浓度也观察到类似的显著降低（分别为 36.2%和 20.8%）（P<0.05）。TC、LDL 和 TG 浓度的降低伴随着血浆高密度脂蛋白浓度的显著增加。结论是，双孢蘑菇在大鼠中具有降血糖和降血脂活性。
