Ye Zhen, Huang Qi, Ni Hai Xiang, Wang Dong
First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, PR China.
Phytother Res. 2008 Dec;22(12):1665-70. doi: 10.1002/ptr.2552.
Here we evaluate the effects of ethanol and aqueous extracts from Cortex Lycii Radicis (CLR) on insulin resistance and lipid metabolism in obese-diabetic rats, which were induced by high fat feeding for 3 weeks after injection with streptozotocin (STZ). Diabetic rats treated with ethanol or aqueous extracts of CLR at 15 and 30 g/kg dosage for 7 weeks, had decreased body weights, concentration of serum glucose, triglyceride (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), while the insulin-sensitivity index (ISI) improved significantly compared with the control group. In addition, high contents of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and low adiponectin level were observed in the control group and levels of TNF-alpha and IL-6 in CLR groups showed obvious differences with the control group. Histopathologic examination also showed degrees of hepatocyte edema although hepatocyte ballooning degeneration was lessened in all CLR groups. Overall, ethanol extract from CLR seemed to be more effective than aqueous extracts in improving insulin resistance, resulted in elevating insulin sensitivity, adjusting glucose and lipid metabolism, correcting cytokines levels and ameliorating liver function, especially protecting the liver against lipoid degeneration.
在此，我们评估了枸杞根皮（CLR）的乙醇提取物和水提取物对肥胖糖尿病大鼠胰岛素抵抗和脂质代谢的影响，这些大鼠是在注射链脲佐菌素（STZ）后通过高脂喂养3周诱导产生的。用CLR的乙醇提取物或水提取物以15和30 g/kg剂量治疗7周的糖尿病大鼠，体重、血清葡萄糖、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）浓度均降低，而胰岛素敏感性指数（ISI）与对照组相比显著改善。此外，对照组中观察到肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）含量高且脂联素水平低，CLR组中TNF-α和IL-6水平与对照组有明显差异。组织病理学检查还显示所有CLR组肝细胞气球样变性减轻，尽管存在一定程度的肝细胞水肿。总体而言，CLR的乙醇提取物在改善胰岛素抵抗、提高胰岛素敏感性、调节糖脂代谢、纠正细胞因子水平和改善肝功能方面似乎比水提取物更有效，尤其能保护肝脏免受脂肪变性。
