Zade Sakshi, Upadhyay Tarun Kumar, Rab Safia Obaidur, Sharangi Amit Baran, Lakhanpal Sorabh, Alabdallah Nadiyah M, Saeed Mohd
Department of Biotechnology, Parul Institute of Applied Sciences and Research and Development Cell, Parul University, Vadodara, 391760, Gujarat, India.
Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.
Discov Oncol. 2025 May 2;16(1):654. doi: 10.1007/s12672-025-02371-z.
Worldwide, cancer is a great cause of death and a public health issue. Cancer has been the leading cause of death in developing nations for many years. Cancers are typically treated with surgery, immunotherapy, chemotherapy, and radiation therapies. However, these techniques have some undesirable side effects, including neurological illness, high toxicity levels, discomfort, and mental stress. Biologically active compounds discovered in mushrooms may be utilized to reduce ill effects and increase the efficacy of the current therapies. Mushrooms have efficient therapeutic activities such as antimicrobial, antitumor, antidiabetic, anticancer, and antioxidant activity. Bioactive compounds like polysaccharides, terpenoids, β-glucan, steroids, polyphenols, flavonoids, proteins, and peptides have precisely well-recognized anticancer activity. In this review paper, we described the biomedical activities of the mushroom against various cancers. The immune-modulating components in mushrooms activate NK cells and macrophages to target cancer cells. Due to immunomodulatory properties of mushroom-derived bioactive compounds in cancer therapy to highlight the need for further research in this area further studies needs to validate in clinical samples.
在全球范围内，癌症是一个主要的死亡原因和公共卫生问题。多年来，癌症一直是发展中国家的首要死因。癌症通常采用手术、免疫疗法、化疗和放射疗法进行治疗。然而，这些技术存在一些不良副作用，包括神经疾病、高毒性水平、不适和精神压力。在蘑菇中发现的生物活性化合物可用于减轻不良影响并提高当前疗法的疗效。蘑菇具有有效的治疗活性，如抗菌、抗肿瘤、抗糖尿病、抗癌和抗氧化活性。多糖、萜类化合物、β-葡聚糖、类固醇、多酚、黄酮类化合物、蛋白质和肽等生物活性化合物具有确切的公认抗癌活性。在这篇综述论文中，我们描述了蘑菇对各种癌症的生物医学活性。蘑菇中的免疫调节成分激活自然杀伤细胞和巨噬细胞以靶向癌细胞。由于蘑菇衍生的生物活性化合物在癌症治疗中的免疫调节特性，为突出该领域进一步研究的必要性，还需要在临床样本中进行进一步研究以验证。
