University of Wisconsin-Madison, Madison, WI, USA.
Thromb Res. 2010 Apr;125(4):287-91. doi: 10.1016/j.thromres.2009.12.017. Epub 2010 Feb 8.
Fibronectin (FN) is a glycoprotein recognized originally in the 1940's as a contaminant of fibrinogen in Cohn fraction I of plasma. Decades of research demonstrated FN synthesis by a variety of cells and defined FN as an essential component of the extracellular matrix with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet thrombus formation and diseases associated with thrombosis including vascular remodeling, atherosclerosis, and cardiac repair following a myocardial infarct. We discuss the mechanisms by which this might occur and conclude that FN may have a unique role in thrombosis without affecting normal hemostasis and therefore may be a reasonable therapeutic target for the prevention of thrombotic diseases.
纤连蛋白（FN）是一种糖蛋白，最初在 20 世纪 40 年代被认为是血浆 Cohn 分馏 I 中纤维蛋白原的污染物。数十年的研究表明，各种细胞都能合成 FN，并将 FN 定义为细胞外基质的重要组成部分，在胚胎发生、发育和伤口愈合中发挥作用。最近，FN 已成为血小板血栓形成以及与血栓形成相关的疾病（包括血管重塑、动脉粥样硬化和心肌梗死后的心脏修复）的重要参与者。我们讨论了可能发生这种情况的机制，并得出结论，FN 可能在不影响正常止血的情况下在血栓形成中发挥独特作用，因此可能是预防血栓性疾病的合理治疗靶点。
