Baraut J, Farge D, Jean-Louis F, Kesmandt H, Durant C, Verrecchia F, Michel L
hôpital Saint-Louis. pavillon Bazin, Paris, France.
Pathol Biol (Paris). 2012 Apr;60(2):127-39. doi: 10.1016/j.patbio.2009.11.003. Epub 2010 Feb 8.
The balance in the production and release of cytokines "Th1/Th2" or "Th17" or "regulatory T" is one of the key events in the pathogenesis of systemic sclerosis (SSc). Specifically, the Th2 cytokine response, characterized by the production of IL-4, IL-10 and TGF-β, leads to tissue fibrosis in patients with SSc. Many studies have shown the importance of analyzing the levels of cytokines as diagnostic or prognostic markers in the blood or in situ in patients with SSc. The restoration of the Th1/Th2/Th17/Treg balance will contribute to the effectiveness of treatment and the use of cytokine modulators may therefore be considered in developing new therapeutic approaches.
细胞因子“Th1/Th2”或“Th17”或“调节性T细胞”的产生与释放平衡是系统性硬化症（SSc）发病机制中的关键事件之一。具体而言，以产生白细胞介素-4、白细胞介素-10和转化生长因子-β为特征的Th2细胞因子反应会导致SSc患者出现组织纤维化。许多研究表明，分析细胞因子水平作为SSc患者血液或原位诊断或预后标志物的重要性。恢复Th1/Th2/Th17/Treg平衡将有助于提高治疗效果，因此在开发新的治疗方法时可考虑使用细胞因子调节剂。
