Institute of Biology and Immunology of Reproduction Acad K Bratanov, Bulgarian Academy of Sciences, 73 Tzarigradsko shosse, 1113 Sofia, Bulgaria.
Reprod Biomed Online. 2010 Mar;20(3):305-13. doi: 10.1016/j.rbmo.2009.12.011. Epub 2009 Dec 16.
This review discusses the presence and characteristics of multipotent stromal cells in human endometrium and decidua. A number of research groups have reported the isolation and characterization of multipotent stromal cells from the basal layer of the endometrium, and in a single case just from the menstrual blood, i.e. the superficial functional layer. Similarly, multipotent pre-decidual stromal cells are isolated from early decidua and characterized accordingly. Multipotent endometrial stromal cells and multipotent decidual stromal cells are shown to express the basic features of adult stem cells, which are clonogenicity, self-renewal, a potential to differentiate into adipogenic, osteogenic, chrondrogenic, endothelial-like cells and a specific set of surface molecules (CD73, CD90 and CD105). So far, it is not clear whether the same population of multipotent stromal cells is isolated from the basal endometrium or early decidua because it has been shown that in some cases the differentiation potential of endometrial stromal cells is more restricted in comparison to the decidual stromal cells. It is reasonable to assume that it is one cell population under different control by hormonal, paracrine and autocrine factors. Thus far, the functions of these cells have not been convincingly revealed.
这篇综述讨论了人子宫内膜和蜕膜中多能基质细胞的存在和特征。许多研究小组已经报道了从子宫内膜的基底层，甚至仅从月经血（即表面功能层）中分离和鉴定多能基质细胞。同样，多能前蜕膜基质细胞也从早期蜕膜中分离出来并进行相应的鉴定。多能子宫内膜基质细胞和多能蜕膜基质细胞表现出成年干细胞的基本特征，包括克隆性、自我更新、向脂肪细胞、成骨细胞、软骨细胞、内皮样细胞分化的潜能以及特定的表面分子（CD73、CD90 和 CD105）。到目前为止，还不清楚是否从基底层子宫内膜或早期蜕膜中分离出相同的多能基质细胞群，因为已经表明，在某些情况下，与蜕膜基质细胞相比，子宫内膜基质细胞的分化潜能受到更多限制。合理的假设是，它是一种受到激素、旁分泌和自分泌因子不同控制的细胞群体。到目前为止，这些细胞的功能还没有被令人信服地揭示出来。
