Department of Gynecology and Obstetrics, University Clinic of Münster, Münster, Germany.
Fertil Steril. 2011 Jan;95(1):423-6. doi: 10.1016/j.fertnstert.2010.08.035.
Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potential; expression of CD146, CD105, CD90, CD73, MSI1, NOTCH1, and SOX2; and absence of CD34 and CD14 expression. We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells.
从子宫内膜活检中获得的体外培养纯化的基质细胞衍生的子宫内膜细胞克隆表现出特征性的干细胞特征，包括克隆性；长期培养特性；多能分化潜能；表达 CD146、CD105、CD90、CD73、MSI1、NOTCH1 和 SOX2；以及缺乏 CD34 和 CD14 的表达。我们得出结论，在常规临床环境下进行的子宫内膜活检中存在成人干细胞，为未来涉及成人干细胞的研究、诊断和治疗提供了新的大规模方法。
