Service d'Histologie et Biologie de la Reproduction, Assistance Publique Hôpitaux de Paris (APHP)-Hôpital Tenon, Paris, France.
Reprod Biomed Online. 2010 Mar;20(3):324-7. doi: 10.1016/j.rbmo.2009.12.003. Epub 2009 Dec 11.
This is a report of a 6-year follow-up of a male patient's semen parameters during heavy chronic alcohol intoxication and after withdrawal. A slowly progressive negative impact of alcohol could be observed: isolated moderate teratozoospermia was firstly noted followed by oligoasthenoteratospermia. Then a severe worsening resulted in cryptozoospermia and ultimately in azoospermia. At this moment, the histological analysis of a testicular biopsy revealed a maturation arrest of the germinal cells at the pachytene stage with no mature sperm cells. Alcohol withdrawal was then obtained, allowing a very fast and drastic improvement of semen characteristics; strictly normal semen parameters were observed after no more than 3 months. Taking into consideration these data, patients should be questioned about their alcohol intake before assisted reproductive technology and should be informed about this adverse effect. Moreover, this case report emphasizes how quickly benefits can be obtained after withdrawal, even in the case of heavy chronic alcohol intake.
这是一份关于一名男性患者在重度慢性酒精中毒期间和戒酒后精液参数进行 6 年随访的报告。可以观察到酒精的缓慢进行性负面影响：首先注意到孤立的中度畸形精子症，随后是少弱精子症。然后严重恶化导致无精子症，最终导致无精子症。此时，睾丸活检的组织学分析显示精母细胞在粗线期停滞，没有成熟的精子细胞。然后进行了戒酒，精液特征得到了非常快速和明显的改善；在不超过 3 个月的时间内观察到严格正常的精液参数。考虑到这些数据，在进行辅助生殖技术之前，应该询问患者关于他们的酒精摄入量，并告知他们这种不良影响。此外，本病例报告强调了即使在重度慢性酒精摄入的情况下，戒酒后也能迅速获益。
