Department of Gynecology, Division of Gynecology and Reproductive Medicine, Fertility Center, Humanitas Research Hospital, IRCCS, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Front Endocrinol (Lausanne). 2023 Oct 5;14:1150951. doi: 10.3389/fendo.2023.1150951. eCollection 2023.
To date, infertility affects 10% to 15% of couples worldwide. A male factor is estimated to account for up to 50% of cases. Oral supplementation with antioxidants could be helpful to improve sperm quality by reducing oxidative damage. At the same time, there is a growing interest in the literature on the use of testicular sperm in patients with high DNA fragmentation index (DFI). This narrative review aims to evaluate the effectiveness of supplementation of oral antioxidants in infertile men with high DFI compared to testicular sperm retrieval. The current evidence is non-conclusive because of serious risk of bias due to small sample sizes and statistical methods. Further large well-designed randomised placebo-controlled trials are still required to clarify the exact role of these to different therapeutic approaches.
迄今为止，全球有 10%至 15%的夫妇受到不孕不育的影响。据估计，男性因素占病例的 50%左右。口服抗氧化剂补充剂可能有助于通过减少氧化损伤来提高精子质量。与此同时，文献中越来越关注使用精子在高 DNA 碎片指数 (DFI) 的患者中。本综述旨在评估与睾丸精子获取相比，口服抗氧化剂补充剂对高 DFI 不孕男性的有效性。由于样本量小和统计方法的严重偏倚风险，目前的证据尚无定论。仍需要进一步进行大型、设计良好的随机安慰剂对照试验，以明确这些治疗方法的确切作用。
