Department of Integrated Biosciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan.
Neurosci Res. 2010 Apr;66(4):406-11. doi: 10.1016/j.neures.2010.01.001. Epub 2010 Feb 1.
In this study, diffusion tensor MRI was used to examine the restoration of the cerebral white matter of macaque monkeys after unilateral cerebral multiple microinfarctions. Post-stroke, the monkeys showed deficits in several neurological functions, including motor functions, but most of the deficits resolved within 6 weeks. Very interestingly, the fractional anisotropy (a value determined by diffusion tensor MRI), of the monkeys' affected motor pathways dropped transiently, indicating a damage in the neural tracts. However, it returned to normal levels within 6 weeks after the stroke, concomitant with the gradual recovery of motor functions at subacute phase.
在这项研究中，我们使用弥散张量 MRI 来检测单侧大脑多发性微梗死后猕猴大脑白质的恢复情况。中风后，猴子出现了多种神经功能障碍，包括运动功能障碍，但大多数缺陷在 6 周内得到解决。非常有趣的是，猴子受影响的运动通路的各向异性分数（由弥散张量 MRI 确定的值）短暂下降，表明神经束受损。然而，在中风后 6 周内，它恢复到正常水平，同时在亚急性期运动功能逐渐恢复。
