Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Clin Gastroenterol Hepatol. 2010 May;8(5):471-3. doi: 10.1016/j.cgh.2010.01.007. Epub 2010 Feb 1.
BACKGROUND & AIMS: Clostridium difficile infection (CDI) can relapse in patients with significant comorbidities. A subset of these patients becomes dependent on oral vancomycin therapy for prolonged periods with only temporary clinical improvement. These patients incur significant morbidity from recurrent diarrhea and financial costs from chronic antibiotic therapy.
We sought to investigate whether self- or family-administered fecal transplantation by low volume enema could be used to definitively treat refractory CDI.
We report a case series (n = 7) where 100% clinical success was achieved in treating these individuals with up to 14 months of follow-up.
Fecal transplantation by low volume enema is an effective and safe option for patients with chronic relapsing CDI, refractory to other therapies. Making this approach available in health care settings has the potential to dramatically increase the number of patients who could benefit from this therapy.
艰难梭菌感染（CDI）可在合并症严重的患者中复发。这些患者中有一部分需要长期依赖口服万古霉素治疗，仅能暂时改善临床症状。这些患者因反复腹泻而遭受严重的发病，因长期使用抗生素而产生经济成本。
我们试图研究是否可以通过小容量灌肠进行自我或家庭粪便移植来彻底治疗难治性 CDI。
我们报告了一个病例系列（n=7），在长达 14 个月的随访中，该方法在治疗这些患者中达到了 100%的临床成功率。
对于其他治疗方法难治的慢性复发性 CDI 患者，小容量灌肠的粪便移植是一种有效且安全的选择。在医疗保健环境中提供这种方法有可能大大增加受益于这种治疗的患者数量。
