Department of Physiotherapy, Communication Science and Disorders, Occupational Therapy, LIM 34, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Respir Physiol Neurobiol. 2010 Mar 31;170(3):246-52. doi: 10.1016/j.resp.2010.01.013. Epub 2010 Feb 1.
Furosemide, a potent diuretic, affects ion and water movement across the respiratory epithelium. However, the effects of furosemide, as clinically used, on mucociliary clearance, a critical respiratory defense mechanism, are still lacking in humans. Fourteen young healthy subjects were assigned to three random interventions, spaced one-week apart: no intervention (control), oral furosemide (40mg), and furosemide+oral volume replacement (F+R). Nasal mucociliary clearance was assessed by saccharine test (STT), and mucus properties were in vitro evaluated by means of contact angle and transportability by sneeze. Urine output and osmolality were also evaluated. Urine output increased and reduced urine osmolality in furosemide and F+R compared to the control condition. STT remained stable in the control group. In contrast, STT increased significantly (40%) after furosemide and F+R. There were no changes in vitro mucus properties in all groups. In conclusion, furosemide prolongs STT in healthy young subjects. This effect is not prevented by fluid replacement, suggesting a direct effect of furosemide on the respiratory epithelium.
速尿，一种强效利尿剂，影响呼吸道上皮的离子和水的运动。然而，临床上使用速尿对黏液纤毛清除功能（一种重要的呼吸防御机制）的影响在人类中仍然缺乏研究。14 名年轻健康受试者被随机分配到三个干预组，间隔一周：无干预（对照组）、口服速尿（40mg）和速尿+口服容量替代（F+R）。鼻黏液纤毛清除功能通过蔗糖试验（STT）评估，黏液特性通过接触角和喷嚏运输能力在体外评估。还评估了尿量和渗透压。与对照组相比，速尿和 F+R 组的尿量增加，尿渗透压降低。对照组的 STT 保持稳定。相比之下，速尿和 F+R 后 STT 显著增加（40%）。所有组的体外黏液特性均无变化。总之，速尿可延长健康年轻受试者的 STT。这种作用不能通过液体替代来预防，提示速尿对呼吸道上皮有直接作用。
