Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, Los Angeles, California 90095-1679, USA.
J Am Coll Cardiol. 2010 Jan 26;55(4):283-93. doi: 10.1016/j.jacc.2009.07.029.
Heart failure (HF) is common, results in poor clinical outcomes, and is associated with large health care costs. The incidence of HF continues to rise, with approximately 670,000 new cases per year and a 20% lifetime risk of HF for persons 40 years and older in the U.S. Risk factors for HF have been identified, and thus preventative strategies should have a positive effect on disease burden, morbidity, and mortality. Although coronary artery disease and hypertension have traditionally been considered among the most important modifiable risk factors for the development of HF, recent studies have highlighted the importance of increasingly prevalent metabolic risk factors: glucose, diabetes, obesity, and the metabolic syndrome. This report will present evidence for the link between glucose, diabetes, obesity, metabolic syndrome, and incident HF. Furthermore, we will discuss how risk factor modification and other preventive therapies may help curb the rising incidence of HF.
心力衰竭（HF）较为常见，会导致不良的临床结局，并与高昂的医疗保健费用相关。HF 的发病率持续上升，在美国，每年约有 67 万人新患 HF，40 岁及以上人群中有 20%的 HF 终生风险。HF 的危险因素已经确定，因此预防策略应该对疾病负担、发病率和死亡率产生积极影响。尽管冠状动脉疾病和高血压传统上被认为是 HF 发展的最重要的可改变危险因素之一，但最近的研究强调了日益流行的代谢危险因素（如葡萄糖、糖尿病、肥胖和代谢综合征）的重要性。本报告将介绍葡萄糖、糖尿病、肥胖、代谢综合征与 HF 发病之间关联的证据。此外，我们还将讨论如何通过改变危险因素和其他预防疗法来帮助遏制 HF 发病率的上升。
