Dept. of Psychiatry, Miguel Servet University Hospital, University of Zaragoza, Zaragoza, Spain.
Psychosomatics. 2010 Jan-Feb;51(1):55-61. doi: 10.1176/appi.psy.51.1.55.
A significant association between joint hypermobility syndrome (JHS) and panic disorder was observed in a sample of rheumatology outpatients.
The aim of this study was to assess whether JHS is more frequent in panic-disorder than in control subjects.
The authors conducted a case-control study comparing 55 untreated patients with panic disorder and three matched-control groups: psychiatric patients, fibromyalgia patients, and healthy persons.
JHS was more frequent among panic-disorder than among psychiatric patients, the healthy group, or the fibromyalgia group. In the panic-disorder group, there was a significant correlation between severity of JHS and anxiety.
The strong association between JHS and panic disorder points to a genetic association. There is also a possibility that JHS and mitral valve prolapse, another condition frequently associated with panic disorder, share a common pathophysiological mechanism.
在一组风湿科门诊患者中，观察到关节过度活动综合征（JHS）与惊恐障碍之间存在显著关联。
本研究旨在评估 JHS 在惊恐障碍患者中是否比在对照组中更为常见。
作者进行了一项病例对照研究，比较了 55 名未经治疗的惊恐障碍患者和三个匹配对照组：精神科患者、纤维肌痛患者和健康人群。
JHS 在惊恐障碍患者中比在精神科患者、健康组或纤维肌痛组中更为常见。在惊恐障碍组中，JHS 的严重程度与焦虑之间存在显著相关性。
JHS 与惊恐障碍之间的强烈关联表明存在遗传关联。此外，JHS 和二尖瓣脱垂之间也可能存在共同的病理生理机制，二尖瓣脱垂是另一种常与惊恐障碍相关的疾病。
