Bulbena A, Duró J C, Porta M, Martín-Santos R, Mateo A, Molina L, Vallescar R, Vallejo J
Department of Psychiatry, Hospital del Mar, Barcelona, Spain.
Psychiatry Res. 1993 Jan;46(1):59-68. doi: 10.1016/0165-1781(93)90008-5.
A case-control study was designed to test the association between joint hypermobility syndrome (JHS), an inherited disorder of collagen synthesis, and anxiety and phobic disorders. One hundred fourteen cases of JHS diagnosed at the rheumatology outpatient clinic of the Hospital del Mar (Barcelona) were compared to 59 control subjects randomly selected from patients seen at the same clinic. Both cases and controls were examined by a psychologist who used the Structured Clinical Interview for DSM-III-R and who was unaware of their medical diagnoses. DSM-III-R diagnoses of panic disorder, agoraphobia, and simple phobia, but not generalized anxiety disorder, dysthymic disorder, or major depression were found to be highly associated with JHS (age- and sex-adjusted odds ratio = 10.7). Mitral valve prolapse (MVP) was present only among JHS cases. Among cases of JHS, subjects with MVP were almost three times more likely to suffer from anxiety than subjects without MVP (odds ratio = 2.95), although the association was not statistically significant. The strong association between panic anxiety and JHS appears to occur at a higher level than the association between panic and MVP, and provides a new basis for further studies on the genetic background of panic-anxiety.
一项病例对照研究旨在测试关节过度活动综合征（JHS，一种遗传性胶原蛋白合成障碍疾病）与焦虑症和恐惧症之间的关联。将在巴塞罗那德尔马医院风湿病门诊诊断出的114例JHS患者与从同一诊所就诊患者中随机选取的59名对照受试者进行比较。病例组和对照组均由一名心理学家进行检查，该心理学家使用《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）的结构化临床访谈，且不知道他们的医学诊断结果。发现DSM-III-R诊断的惊恐障碍、广场恐惧症和单纯恐惧症，但不包括广泛性焦虑障碍、心境恶劣障碍或重度抑郁症，与JHS高度相关（年龄和性别调整后的优势比 = 10.7）。二尖瓣脱垂（MVP）仅在JHS病例中出现。在JHS病例中，患有MVP的受试者患焦虑症的可能性几乎是未患MVP受试者的三倍（优势比 = 2.95），尽管这种关联在统计学上并不显著。惊恐焦虑与JHS之间的强关联似乎比惊恐与MVP之间的关联更为显著，并为进一步研究惊恐焦虑的遗传背景提供了新的依据。
