Department of Infectious Diseases, Division of Medical Microbiology, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.
Biol Pharm Bull. 2010;33(2):188-91. doi: 10.1248/bpb.33.188.
Phx-3, one of the phenoxazine derivatives, is reported to have inhibitory effect on Mycobacterium species and Chlamydia pneumoniae but not Escherichia coli, Salmonella Typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus, Listeria monocytogenes. The bactericidal activities of Phx-3 against Helicobacter pylori strains have not been assessed. Then, we measured minimum inhibitory concentration of Phx-3 for Helicobacter strains and assessed the morphological and biochemical effects of Phx-3 on H. pylori. In present study, it has shown that H. pylori strains including clarithromycin resistant strain and Helicobacter musterae were killed effectively by the treatment with Phx-3. Furthermore, severe morphological changes such as membrane blebbing and formation of hollows in H. pylori were detected. In addition, induction of heat shock protein 60 was observed. Taken together, Phx-3 has antibacterial activity against Helicobacter pylori.
Phx-3 是一种吩嗪衍生物，据报道它对分枝杆菌属和肺炎衣原体有抑制作用，但对大肠杆菌、沙门氏菌、铜绿假单胞菌、金黄色葡萄球菌、李斯特菌无效。尚未评估 Phx-3 对幽门螺杆菌株的杀菌活性。然后，我们测量了 Phx-3 对幽门螺杆菌的最小抑菌浓度，并评估了 Phx-3 对 H. pylori 的形态和生化影响。在本研究中，表明 Phx-3 可有效杀灭包括克拉霉素耐药株在内的幽门螺杆菌菌株。此外，还观察到幽门螺杆菌出现严重的形态变化，如细胞膜起泡和形成空洞。此外，还观察到热休克蛋白 60 的诱导。总之，Phx-3 对幽门螺杆菌具有抗菌活性。
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