月经对阴道液中 Y 染色体清除的影响：对近期性行为生物标志物的启示。
Effect of menses on clearance of Y-chromosome in vaginal fluid: implications for a biomarker of recent sexual activity.
机构信息
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
出版信息
Sex Transm Dis. 2010 Jan;37(1):1-4. doi: 10.1097/OLQ.0b013e3181b5f15d.
Abstract
Self-reported sexual behaviors are subject to bias. We previously developed a polymerase chain reaction for the detection of Y-chromosome sequences in vaginal fluid as a potential biomarker of recent sexual activity. In this study, we found menses results in lower Y-chromosome concentrations but with similar decay patterns as non-menstrual samples.
摘要
自我报告的性行为可能存在偏差。我们之前开发了一种聚合酶链反应，用于检测阴道液中的 Y 染色体序列，作为近期性行为的潜在生物标志物。在这项研究中，我们发现月经期间的 Y 染色体浓度较低，但与非月经期样本的衰减模式相似。
相似文献
1
Effect of menses on clearance of Y-chromosome in vaginal fluid: implications for a biomarker of recent sexual activity.月经对阴道液中 Y 染色体清除的影响：对近期性行为生物标志物的启示。
Sex Transm Dis. 2010 Jan;37(1):1-4. doi: 10.1097/OLQ.0b013e3181b5f15d.
2
Polymerase chain reaction detection of Y chromosome sequences in vaginal fluid: preliminary studies of a potential biomarker for sexual behavior.阴道液中Y染色体序列的聚合酶链反应检测：性行为潜在生物标志物的初步研究
Sex Transm Dis. 2005 Feb;32(2):90-4. doi: 10.1097/01.olq.0000149668.08740.91.
3
Polymerase chain reaction detection of Y-chromosome sequences in vaginal fluid of women accessing a sexually transmitted disease clinic.对前往性传播疾病诊所就诊女性阴道分泌物中Y染色体序列进行聚合酶链反应检测。
Sex Transm Dis. 2006 Jan;33(1):22-5. doi: 10.1097/01.olq.0000194600.83825.81.
4
Y Chromosome DNA in Women's Vaginal Samples as a Biomarker of Recent Vaginal Sex and Condom Use With Male Partners in the HPV Infection and Transmission Among Couples Through Heterosexual Activity Cohort Study.女性阴道样本中的 Y 染色体 DNA 作为近期阴道性行为和与男性伴侣使用避孕套的生物标志物：通过异性活动队列研究中的 HPV 感染和传播。
Sex Transm Dis. 2018 Jan;45(1):28-34. doi: 10.1097/OLQ.0000000000000688.
5
Y chromosome and HIV DNA detection in vaginal swabs as biomarkers of semen and HIV exposure in women.阴道拭子中Y染色体和HIV DNA检测作为女性精液和HIV暴露生物标志物的研究
Sex Transm Dis. 2014 Nov;41(11):674-9. doi: 10.1097/OLQ.0000000000000191.
6
Condom use and vaginal Y-chromosome detection: the specificity of a potential biomarker.避孕套使用与阴道Y染色体检测：一种潜在生物标志物的特异性
Sex Transm Dis. 2007 Aug;34(8):620-3. doi: 10.1097/01.olq.0000258318.99606.d9.
7
Sexual intercourse during menstruation and self-reported sexually transmitted disease history among women.月经期间的性行为与女性自我报告的性传播疾病史
Sex Transm Dis. 1996 Sep-Oct;23(5):395-401. doi: 10.1097/00007435-199609000-00009.
8
Detection and quantification of Y-chromosomal sequences by real-time PCR using the LightCycler system.使用LightCycler系统通过实时PCR检测和定量Y染色体序列。
Sex Transm Dis. 2007 Aug;34(8):617-9. doi: 10.1097/01.olq.0000258336.65285.31.
9
Semen says: assessing the accuracy of adolescents' self-reported sexual abstinence using a semen Y-chromosome biomarker.塞门说：使用精液Y染色体生物标志物评估青少年自我报告的性禁欲的准确性。
Sex Transm Infect. 2017 Mar;93(2):145-147. doi: 10.1136/sextrans-2016-052605. Epub 2016 May 4.
10
Assessment of the vaginal residence time of biomarkers of semen exposure.精液暴露生物标志物阴道停留时间的评估。
Contraception. 2016 Nov;94(5):512-520. doi: 10.1016/j.contraception.2016.05.012. Epub 2016 May 31.
引用本文的文献
1
Alignment of PrEP Use With Potential HIV Exposure in Young Women and Men in Uganda.乌干达年轻女性和男性中暴露前预防用药与潜在艾滋病毒暴露的一致性
J Acquir Immune Defic Syndr. 2025 Apr 1;98(4):326-333. doi: 10.1097/QAI.0000000000003573. Epub 2025 Feb 19.
2
A Comparison of Self-reported Condomless Sex and Yc-DNA Biomarker Data from Young Women Engaged in High Risk Sexual Activity in Kampala, Uganda.乌干达坎帕拉从事高风险性行为的年轻女性的自我报告无保护性行为和 Y 染色体 DNA 生物标志物数据比较。
AIDS Behav. 2024 Jan;28(1):320-331. doi: 10.1007/s10461-023-04177-y. Epub 2023 Sep 26.
3
The Impact of Semen Exposure on the Immune and Microbial Environments of the Female Genital Tract.精液暴露对女性生殖道免疫和微生物环境的影响。
Front Reprod Health. 2020 Nov 9;2:566559. doi: 10.3389/frph.2020.566559. eCollection 2020.
4
Transient association between semen exposure and biomarkers of genital inflammation in South African women at risk of HIV infection.南非感染 HIV 风险女性中精液暴露与生殖系统炎症生物标志物之间的短暂关联。
J Int AIDS Soc. 2021 Jun;24(6):e25766. doi: 10.1002/jia2.25766.
5
A novel nested polymerase chain reaction targeting the testis-specific protein Y-encoded family of genes for high sensitivity of recent semen exposure detection: Comparison with four other assays of semen detection.一种新型的巢式聚合酶链反应，针对睾丸特异性蛋白 Y 编码家族基因，用于高灵敏度的近期精液暴露检测：与其他四种精液检测方法的比较。
PLoS One. 2019 Jul 25;14(7):e0220326. doi: 10.1371/journal.pone.0220326. eCollection 2019.
6
Patterns in On-time, Daily Submission of a Short Web-Based Personal Behavior Survey in a Longitudinal Women's Health Study.基于网络的个人行为短问卷在纵向女性健康研究中的按时、每日提交模式。
Sex Transm Dis. 2019 Aug;46(8):e80-e82. doi: 10.1097/OLQ.0000000000001001.
7
Daily Vaginal Swabs and Mobile Phone Sex Report for Assessing HIV Virion Exposure Prospectively Among a Cohort of Young Sexually Active Women in South Africa (HVTN 915).南非年轻活跃女性队列中前瞻性评估 HIV 病毒暴露的每日阴道拭子和手机性行为报告（HVTN 915）。
J Acquir Immune Defic Syndr. 2019 Jun 1;81(2):e39-e48. doi: 10.1097/QAI.0000000000002015.
8
Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection.在 HIV-1 感染早期，阴道内的序列多样性高于血液。
PLoS Pathog. 2018 Jan 18;14(1):e1006754. doi: 10.1371/journal.ppat.1006754. eCollection 2018 Jan.
9
Estimating HPV DNA Deposition Between Sexual Partners Using HPV Concordance, Y Chromosome DNA Detection, and Self-reported Sexual Behaviors.利用人乳头瘤病毒（HPV）一致性、Y染色体DNA检测及自我报告的性行为来估计性伴侣间HPV DNA的传播情况
J Infect Dis. 2017 Dec 5;216(10):1210-1218. doi: 10.1093/infdis/jix477.
10
Y Chromosome DNA in Women's Vaginal Samples as a Biomarker of Recent Vaginal Sex and Condom Use With Male Partners in the HPV Infection and Transmission Among Couples Through Heterosexual Activity Cohort Study.女性阴道样本中的 Y 染色体 DNA 作为近期阴道性行为和与男性伴侣使用避孕套的生物标志物：通过异性活动队列研究中的 HPV 感染和传播。
Sex Transm Dis. 2018 Jan;45(1):28-34. doi: 10.1097/OLQ.0000000000000688.
本文引用的文献
1
Y-STR profiling in extended interval (> or = 3 days) postcoital cervicovaginal samples.性交后3天及以上的宫颈阴道样本中的Y染色体短串联重复序列（Y-STR）分析。
J Forensic Sci. 2008 Mar;53(2):342-8. doi: 10.1111/j.1556-4029.2008.00672.x.
2
Why do women douche? A longitudinal study with two analytic approaches.女性为什么进行阴道灌洗？一项采用两种分析方法的纵向研究。
Ann Epidemiol. 2008 Jan;18(1):65-73. doi: 10.1016/j.annepidem.2007.05.015.
3
Biomarkers of semen in the vagina: applications in clinical trials of contraception and prevention of sexually transmitted pathogens including HIV.阴道内精液生物标志物：在避孕及预防性传播病原体（包括艾滋病毒）临床试验中的应用
Contraception. 2007 Jun;75(6):407-19. doi: 10.1016/j.contraception.2007.02.007. Epub 2007 Apr 30.
4
Detection and quantification of Y-chromosomal sequences by real-time PCR using the LightCycler system.使用LightCycler系统通过实时PCR检测和定量Y染色体序列。
Sex Transm Dis. 2007 Aug;34(8):617-9. doi: 10.1097/01.olq.0000258336.65285.31.
5
Condom use and vaginal Y-chromosome detection: the specificity of a potential biomarker.避孕套使用与阴道Y染色体检测：一种潜在生物标志物的特异性
Sex Transm Dis. 2007 Aug;34(8):620-3. doi: 10.1097/01.olq.0000258318.99606.d9.
6
Two methods of self-sampling compared to clinician sampling to detect reproductive tract infections in Gugulethu, South Africa.在南非古古莱图，将两种自我采样方法与临床医生采样方法进行比较，以检测生殖道感染。
Sex Transm Dis. 2006 Aug;33(8):516-23. doi: 10.1097/01.olq.0000204671.62529.1f.
7
Application of the case-crossover design to reduce unmeasured confounding in studies of condom effectiveness.应用病例交叉设计以减少避孕套有效性研究中未测量的混杂因素。
Am J Epidemiol. 2005 Apr 15;161(8):765-73. doi: 10.1093/aje/kwi094.
8
Polymerase chain reaction detection of Y chromosome sequences in vaginal fluid: preliminary studies of a potential biomarker for sexual behavior.阴道液中Y染色体序列的聚合酶链反应检测：性行为潜在生物标志物的初步研究
Sex Transm Dis. 2005 Feb;32(2):90-4. doi: 10.1097/01.olq.0000149668.08740.91.
9
Acceptability of a self-sampling technique to collect vaginal smears for gram stain diagnosis of bacterial vaginosis.一种用于收集阴道涂片以进行革兰氏染色诊断细菌性阴道病的自我采样技术的可接受性。
Womens Health Issues. 2004 Jan-Feb;14(1):14-8. doi: 10.1016/j.whi.2003.12.001.
10
NIMH/APPC workgroup on behavioral and biological outcomes in HIV/STD prevention studies: a position statement.美国国立精神卫生研究所/艾滋病预防研究中的行为与生物学结果应用研究项目协作组：一份立场声明。
Sex Transm Dis. 2000 Mar;27(3):127-32. doi: 10.1097/00007435-200003000-00001.
Zotero 插件