[Cellular and humoral immunity in patients with chronic bronchitis and hereditary variants of alpha 1-proteinase inhibitor].

Cellular and humoral immunity was investigated in practically healthy subjects with PLM allele subtypes in the homozygotic form, PiM3M3 phenotypical variants and normal phenotypical variant PiM1M1 in the presence of which practically healthy subjects show a 100% antitryptic activity in the blood serum. A study of the immunological reactivity of 225 patients with chronic obstructive bronchitis revealed in these patients disorders of the cellular and humoral immunity and they were more pronounced in patients with PiM3M3 phenotypical variant.