Department of Neonatology, Kaplan Medical Center, Rehovot, Israel.
J Perinatol. 2010 Feb;30(2):149-50. doi: 10.1038/jp.2009.66.
The inability to appropriately ventilate neonates shortly after their birth could be related in rare cases to chest-wall rigidity caused by the placental transfer of fentanyl. Although this adverse effect is recognized when fentanyl is administered to neonates after their birth, the prenatal phenomenon is less known. Treatment with either naloxone or muscle relaxants reverses the fentanyl effect and may prevent unnecessary excessive ventilatory settings.
新生儿出生后不久无法适当通气的情况，在极少数情况下可能与胎盘转移芬太尼引起的胸壁僵硬有关。虽然在新生儿出生后给予芬太尼时会认识到这种不良反应，但产前现象知之甚少。纳洛酮或肌肉松弛剂的治疗可逆转芬太尼的作用，并可能防止不必要的过度通气设置。
