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木质胸廓综合征:芬太尼诱导的胸廓壁僵硬病例报告。

Wooden Chest Syndrome: A Case Report of Fentanyl-Induced Chest Wall Rigidity.

机构信息

Abington Memorial Hospital-Jefferson Health, Abington, PA, USA.

出版信息

J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211034036. doi: 10.1177/23247096211034036.

DOI:10.1177/23247096211034036
PMID:34301155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8312149/
Abstract

Wooden chest syndrome (WCS) describes a finding of fentanyl-induced skeletal muscle rigidity causing ventilatory failure. Known primarily to anesthesiology, pulmonary, and critical care fields, WCS is a rare complication that may affect patients of all ages if exposed to intravenous fentanyl, characterized by a patient's inability to properly ventilate. Given the rise of synthetic opioid deaths across the United States in the past decade, an understanding of all of fentanyl's effects on the body is necessary. In this article, we present a case of WCS in a patient with acute respiratory distress syndrome in a 61-year-old female.

摘要

木质胸部综合征(WCS)描述了一种芬太尼引起的骨骼肌僵硬导致通气衰竭的现象。主要为麻醉学、肺病学和重症监护领域所熟知,WCS 是一种罕见的并发症,如果患者暴露于静脉内芬太尼,可能会影响所有年龄段的患者,其特征是患者无法正常通气。鉴于过去十年美国合成阿片类药物死亡人数的上升,有必要了解芬太尼对身体的所有影响。在本文中,我们报告了一例 61 岁女性急性呼吸窘迫综合征患者的 WCS 病例。

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J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211034036. doi: 10.1177/23247096211034036.
2
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本文引用的文献

1
Fentanyl-Associated Serotonin Syndrome and Chest Wall Rigidity in an Intensive Care Unit Patient.一名重症监护病房患者出现的芬太尼相关血清素综合征和胸壁强直
Am J Ther. 2019 Sep/Oct;26(5):e612-e614. doi: 10.1097/MJT.0000000000000813.
2
Opioids and Chest Wall Rigidity During Mechanical Ventilation.机械通气期间的阿片类药物与胸壁僵硬
Ann Intern Med. 2018 May 1;168(9):678. doi: 10.7326/L17-0612. Epub 2018 Jan 9.
3
Could chest wall rigidity be a factor in rapid death from illicit fentanyl abuse?胸壁僵硬会是非法芬太尼滥用导致快速死亡的一个因素吗?
Clin Toxicol (Phila). 2016 Jun;54(5):420-3. doi: 10.3109/15563650.2016.1157722. Epub 2016 Mar 21.
4
Fentanyl-induced chest wall rigidity.芬太尼导致的胸壁僵硬。
Chest. 2013 Apr;143(4):1145-1146. doi: 10.1378/chest.12-2131.
5
Effect of levallorphan tartrate upon opiate induced respiratory depression.酒石酸左洛啡烷对阿片类药物所致呼吸抑制的作用。
Anesthesiology. 1953 Nov;14(6):550-4. doi: 10.1097/00000542-195311000-00002.
6
Active transport of fentanyl by the blood-brain barrier.芬太尼通过血脑屏障的主动转运。
J Pharmacol Exp Ther. 1999 May;289(2):1084-9.