Hoehn-Saric R, McLeod D R, Zimmerli W D
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Acta Psychiatr Scand. 1991 Jan;83(1):4-11. doi: 10.1111/j.1600-0447.1991.tb05503.x.
To determine whether panic disorder patients exhibit physiological hyperarousal during rest or during mild, non-panic-inducing stress, 18 patients who experienced frequent panic attacks were compared with nonanxious controls on a battery of physiological assessments. During baseline, patients with panic disorder exhibited higher forehead electromyographic activity, higher systolic blood pressure and higher heart rates than non-anxious volunteers. During psychological stress, heart rate and systolic blood pressure rose more in patients with panic disorder than in nonanxious controls. The skin conductance response, however, was greater and more variable in the nonanxious controls. The results suggest that panic disorder patients with frequent panic attacks exhibit heightened cardiovascular arousal and decreased electrodermal flexibility than nonanxious people, even in nonthreatening situations.
为了确定惊恐障碍患者在休息时或在轻度、不会诱发惊恐的应激状态下是否会出现生理上的过度觉醒，研究人员对18名经常经历惊恐发作的患者与非焦虑对照组进行了一系列生理评估比较。在基线期，惊恐障碍患者比非焦虑志愿者表现出更高的前额肌电活动、更高的收缩压和更高的心率。在心理应激期间，惊恐障碍患者的心率和收缩压升高幅度比非焦虑对照组更大。然而，非焦虑对照组的皮肤电反应更大且更具变异性。结果表明，即使在无威胁的情况下，经常经历惊恐发作的惊恐障碍患者比非焦虑人群表现出更高的心血管觉醒水平和更低的皮肤电灵活性。
