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结直肠癌患者的静脉血栓栓塞性疾病

Venous thromboembolic disease in colorectal patients.

作者信息

McNally Michael P, Burns Christopher J

机构信息

Department of Surgery, Division of Colon and Rectal Surgery, National Naval Medical Center, Bethesda, MD 20889, USA.

出版信息

Clin Colon Rectal Surg. 2009 Feb;22(1):34-40. doi: 10.1055/s-0029-1202884.

DOI:10.1055/s-0029-1202884
PMID:20119554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2780231/
Abstract

Venous thromboembolic disease, which includes deep vein thromboses as well as pulmonary emboli, can be a significant complication in the postoperative patient. In particular, colorectal patients often carry a higher risk for venous thromboembolism when compared with patients undergoing other operative procedures. Features unique to colorectal patients are the high incidence of inflammatory bowel disease or malignancy. Typically, these patients will undergo lengthy pelvic procedures, which also contribute to a cumulative risk of venous thrombosis. It is critical that all patients and the proposed operative procedure are appropriately risk stratified. Risk stratification allows for easier implementation of an appropriate prophylactic strategy. There are a wide range of safe and effective mechanical and pharmacologic measures available. The authors provide very specific recommendations, but note that clinical judgment plays a significant role.

摘要

静脉血栓栓塞性疾病,包括深静脉血栓形成以及肺栓塞,可能是术后患者的一个重要并发症。特别是,与接受其他手术的患者相比,结直肠手术患者发生静脉血栓栓塞的风险通常更高。结直肠患者独有的特征是炎症性肠病或恶性肿瘤的高发病率。通常,这些患者将接受长时间的盆腔手术,这也会增加静脉血栓形成的累积风险。对所有患者和拟行的手术进行适当的风险分层至关重要。风险分层有助于更轻松地实施适当的预防策略。有多种安全有效的机械和药物措施可供选择。作者提供了非常具体的建议,但指出临床判断起着重要作用。

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High preoperative prevalence of deep venous thrombosis in patients with colorectal cancer.结直肠癌患者术前深静脉血栓形成的高患病率。
Br J Surg. 2007 Sep;94(9):1100-3. doi: 10.1002/bjs.5754.
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Hospitals' compliance with prophylaxis guidelines for venous thromboembolism.医院对静脉血栓栓塞预防指南的遵循情况。
Am J Health Syst Pharm. 2007 Jan 1;64(1):69-76. doi: 10.2146/ajhp060115.
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Prolonged prophylaxis with dalteparin to prevent late thromboembolic complications in patients undergoing major abdominal surgery: a multicenter randomized open-label study.使用达肝素进行长期预防以防止接受大腹部手术患者的晚期血栓栓塞并发症:一项多中心随机开放标签研究。
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7
Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery.术后使用磺达肝癸钠与围手术期使用达肝素预防高危腹部手术静脉血栓栓塞的随机临床试验
Br J Surg. 2005 Oct;92(10):1212-20. doi: 10.1002/bjs.5154.
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Age- and sex-specific incidence, risk, and latency period of a perioperative acute thromboembolism syndrome (PATS).围手术期急性血栓栓塞综合征(PATS)的年龄和性别特异性发病率、风险及潜伏期
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