结直肠癌患者术前深静脉血栓形成的高患病率。
High preoperative prevalence of deep venous thrombosis in patients with colorectal cancer.
作者信息
Stender M T, Nielsen T S H, Frøkjaer J B, Larsen T B, Lundbye-Christensen S, Thorlacius-Ussing O
机构信息
Department of Surgical Gastroenterology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, DK-9100 Aalborg, Denmark.
出版信息
Br J Surg. 2007 Sep;94(9):1100-3. doi: 10.1002/bjs.5754.
BACKGROUND
Deep venous thrombosis (DVT) is a major complication of cancer and a predictor of reduced survival. The postoperative prevalence of DVT in colorectal cancer surgery is high, but the preoperative prevalence is unknown. The aim of this observational study was to estimate the preoperative prevalence of DVT in patients with colorectal cancer.
METHODS
Some 193 consecutive patients with newly diagnosed colorectal cancer admitted for intended curative surgery were examined with compression ultrasonography for DVT before surgery.
RESULTS
DVT was detected in 15 (7.8 per cent) of the 193 patients, with a prevalence of 16 per cent in women (12 of 76) versus 2.6 per cent in men (three of 117 (adjusted odds ratio (OR) 5.8 (95 per cent confidence interval (c.i.) 1.4 to 23.2)). The risk of DVT was strongly correlated with increasing American Society of Anesthesiologists (ASA) risk score: adjusted OR 6.8 (95 per cent c.i. 1.6 to 28.7 for ASA group III or IV versus ASA group I or II). Pulmonary embolism was detected in two patients (1.0 per cent).
CONCLUSION
A high preoperative prevalence of DVT was observed in patients with colorectal cancer, especially among women and patients in ASA groups III and IV.
背景
深静脉血栓形成（DVT）是癌症的一种主要并发症，也是生存率降低的一个预测指标。结直肠癌手术中DVT的术后患病率较高，但术前患病率尚不清楚。这项观察性研究的目的是评估结直肠癌患者术前DVT的患病率。
方法
对193例连续入院拟行根治性手术的新诊断结直肠癌患者在术前采用加压超声检查DVT。
结果
193例患者中有15例（7.8%）检测到DVT，女性患病率为16%（76例中有12例），男性为2.6%（117例中有3例）（校正比值比（OR）5.8（95%置信区间（c.i.）1.4至23.2））。DVT风险与美国麻醉医师协会（ASA）风险评分增加密切相关：ASA III或IV组与ASA I或II组相比，校正OR为6.8（95% c.i. 1.6至28.7）。2例患者（1.0%）检测到肺栓塞。
结论
结直肠癌患者术前DVT患病率较高，尤其是女性以及ASA III和IV组患者。
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