Jauhiainen A, Räsänen K, Sarantila R, Nuutinen J, Kangas J
Kuopio Regional Institute of Occupational Health, Finland.
Am Ind Hyg Assoc J. 1991 Feb;52(2):61-4. doi: 10.1080/15298669191364334.
The purpose of this study was to measure forest workers' exposure to the herbicide glyphosate during silvicultural clearing work done with brush saws equipped with pressurized herbicide sprayers. Both the exposed (study) group and the nonexposed (control) group contained five persons who were medically examined before and after their 1-week working period (including laboratory tests) for possible health effects. In addition, exposure to glyphosate was measured in the study group from samples taken from the workers' breathing zone and from urine samples collected during the afternoons of the workweek. The laboratory tests and urinary glyphosate analyses were repeated for the exposed group 3 weeks later, when the men had entirely stopped their work with the herbicide. Exposure to glyphosate through the workers' breathing zone was low. The highest value found was 15.7 micrograms/m3. In this study, a biological monitoring method was also developed to monitor the workers' exposure to glyphosate. Urine concentrations were under the gas chromatographic detection level of less than 0.1 ng/microL (less than 1.0 mumol/L). No major differences were noted, either in medical examinations or in the laboratory tests performed, between the exposed and control groups before and after the work period.
本研究的目的是测量林业工人在使用配备加压除草剂喷雾器的割灌机进行造林清理工作期间接触除草剂草甘膦的情况。暴露组（研究组）和非暴露组（对照组）均有五人，在为期1周的工作期前后接受了医学检查（包括实验室检测），以评估可能的健康影响。此外，在研究组中，从工人呼吸区采集样本以及在工作周下午收集尿液样本，以测量草甘膦暴露情况。3周后，当这些男性完全停止使用除草剂工作时，对暴露组再次进行了实验室检测和尿草甘膦分析。通过工人呼吸区接触草甘膦的水平较低。所发现的最高值为15.7微克/立方米。在本研究中，还开发了一种生物监测方法来监测工人接触草甘膦的情况。尿液浓度低于气相色谱检测水平，即低于0.1纳克/微升（低于1.0微摩尔/升）。在工作期前后，暴露组和对照组在医学检查或所进行的实验室检测中均未发现重大差异。
