Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Ehime - Japan.
J Nephrol. 2010 Mar-Apr;23(2):175-80.
In patients with essential hypertension (EHT), the intrarenal resistance index (RI) has been shown to be related to the severity of target organ damage (TOD). Cystatin C is has been reported to be related to TOD in EHT. The aim of the present study was to clarify whether the RI predicts future renal function assessed by cystatin C levels in EHT.
One-hundred and twelve patients participated. RI and cystatin C were measured at baseline, and 12 months later, cystatin C was measured again.
The patients were divided into 2 groups according to RI value: the low RI group (RI<0.7) and the high RI group (RI> or =0.7). After 12 months, cystatin C levels were significantly elevated in the high RI group, whereas the levels remained unchanged in the low RI group. Stepwise regression analysis using the baseline values of RI, age, pulse pressure, HbA1c, cystatin C, log-transformed (ln) C-reactive protein and ln urinary albumin/creatinine as covariates, showed baseline RI was the only independent determinant of the time-related changes in cystatin C levels.
This finding suggests that the renal RI may be a marker of future renal dysfunction in EHT.
在原发性高血压（EHT）患者中，肾内阻力指数（RI）与靶器官损害（TOD）的严重程度相关。胱抑素 C 已被报道与 EHT 中的 TOD 相关。本研究旨在阐明 RI 是否可预测 EHT 患者未来的肾功能（由胱抑素 C 水平评估）。
共有 112 名患者参与了该研究。在基线时测量 RI 和胱抑素 C，12 个月后再次测量胱抑素 C。
根据 RI 值将患者分为两组：低 RI 组（RI<0.7）和高 RI 组（RI≥0.7）。12 个月后，高 RI 组的胱抑素 C 水平显著升高，而低 RI 组的水平保持不变。使用 RI、年龄、脉压、HbA1c、胱抑素 C、ln 型 C 反应蛋白和 ln 型尿白蛋白/肌酐的基线值作为协变量的逐步回归分析显示，基线 RI 是胱抑素 C 水平随时间变化的唯一独立决定因素。
这一发现表明，肾脏 RI 可能是 EHT 患者未来肾功能障碍的标志物。
