从田野阿魏（伞形科）根部分离出的天然香豆素以及aegelinol的合成酯衍生物的细胞毒性特性。
The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol.
作者信息
Rosselli Sergio, Maggio Antonella Maria, Faraone Nicoletta, Spadaro Vivienne, Morris-Natschke Susan L, Bastow Kenneth F, Lee Kuo-Hsiung, Bruno Maurizio
机构信息
Dipartimento Chimica Organica "E. Paternò ", Università di Palermo, Viale delle Scienze, Parco d'Orleasn II, 90128 Palermo, Italy.
出版信息
Nat Prod Commun. 2009 Dec;4(12):1701-6.
Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.
从田野阿魏（Ferulago campestris）中分离得到的四种天然香豆素——大维亭（Grandivittin，1）、阿加索林（agasyllin，2）、阿盖利诺苯甲酸酯（aegelinol benzoate，3）和费拉米丁（felamidin，20），以及阿盖利诺的几种合成酯衍生物（4），针对四种肿瘤细胞系进行了测试。结果显示，其中一些化合物对A549肺癌细胞系具有轻微的细胞毒性。
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