从马达加斯加栓皮栎（Phellolophium madagascariense Baker）中分离得到的异戊烯基香豆素的抗增殖作用

Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker.

作者信息

Riviere C, Goossens L, Pommery N, Fourneau C, Delelis A, Henichart J P

机构信息

Institut de Chimie Pharmaceutique Albert Lespagnol, EA2692, rue J. Laguesse, BP 83, F-59006 Lille, France.

出版信息

Nat Prod Res. 2006 Aug;20(10):909-16. doi: 10.1080/14786410500277787.

DOI:10.1080/14786410500277787

PMID:16854718

Abstract

From the leaves of Phellolophium madagascariense Baker (Apiaceae), an endemic herb to Madagascar, three known coumarins (osthol, murraol and meranzin hydrate) have been isolated and identified. This is the first report of these compounds in this species. The structural elucidations were based on the analysis of physical and spectroscopic data. The anticancer activity of the three isolated compounds and of a synthetic sample of osthol was evaluated on L1210 mouse leukemia and on human prostatic cancer hormonosensitive LNCaP and hormonoindependent PC3 and DU145 cell lines.

摘要

从马达加斯加特有的草本植物马达加斯加黄皮叶（伞形科）中，已分离并鉴定出三种已知的香豆素（蛇床子素、穆拉醇和水合橙皮素）。这是这些化合物在该物种中的首次报道。结构解析基于物理和光谱数据的分析。对三种分离出的化合物以及蛇床子素的合成样品对L1210小鼠白血病细胞以及人前列腺癌激素敏感LNCaP细胞、激素非依赖PC3细胞和DU145细胞系的抗癌活性进行了评估。