Qureshi A A, Qureshi N, Hasler-Rapacz J O, Weber F E, Chaudhary V, Crenshaw T D, Gapor A, Ong A S, Chong Y H, Peterson D
Advanced Medical Research, Madison, WI 53719.
Am J Clin Nutr. 1991 Apr;53(4 Suppl):1042S-1046S. doi: 10.1093/ajcn/53.4.1042S.
Normolipemic and genetically hypercholesterolemic pigs of defined lipoprotein genotype were fed a standard diet supplemented with 50 micrograms/g tocotrienol-rich fraction (TRF) isolated from palm oil. Hypercholesterolemic pigs fed the TRF supplement showed a 44% decrease in total serum cholesterol, a 60% decrease in low-density-lipoprotein (LDL)-cholesterol, and significant decreases in levels of apolipoprotein B (26%), thromboxane-B2 (41%), and platelet factor 4 (PF4; 29%). The declines in thromboxane B2 and PF4 suggest that TRF has a marked protective effect on the endothelium and platelet aggregation. The effect of the lipid-lowering diet persisted only in the hypercholesterolemic swine after 8 wk feeding of the control diet. These results support observations from previous studies on lowering plasma cholesterol in animals by tocotrienols, which are naturally occurring compounds in grain and palm oils and may have some effect on lowering plasma cholesterol in humans.
给具有特定脂蛋白基因型的血脂正常和遗传性高胆固醇血症猪喂食添加了从棕榈油中分离出的50微克/克富含生育三烯酚组分（TRF）的标准饮食。喂食TRF补充剂的高胆固醇血症猪的总血清胆固醇降低了44%，低密度脂蛋白（LDL）胆固醇降低了60%，载脂蛋白B水平（降低26%）、血栓素B2（降低41%）和血小板因子4（PF4；降低29%）也显著降低。血栓素B2和PF4的下降表明TRF对内皮和血小板聚集有显著的保护作用。在喂食对照饮食8周后，降血脂饮食的效果仅在高胆固醇血症猪中持续存在。这些结果支持了先前关于生育三烯酚降低动物血浆胆固醇的研究观察结果，生育三烯酚是谷物和棕榈油中的天然化合物，可能对降低人类血浆胆固醇有一定作用。
