Qureshi A A, Qureshi N, Wright J J, Shen Z, Kramer G, Gapor A, Chong Y H, DeWitt G, Ong A, Peterson D M
Advanced Medical Research, Madison, WI 53719.
Am J Clin Nutr. 1991 Apr;53(4 Suppl):1021S-1026S. doi: 10.1093/ajcn/53.4.1021S.
A double-blind, crossover, 8-wk study was conducted to compare effects of the tocotrienol-enriched fraction of palm oil (200 mg palmvitee capsules/day) with those of 300 mg corn oil/d on serum lipids of hypercholesterolemic human subjects (serum cholesterol 6.21-8.02 mmol/L). Concentrations of serum total cholesterol (-15%), LDL cholesterol (-8%), Apo B (-10%), thromboxane (-25%), platelet factor 4 (-16%), and glucose (-12%) decreased significantly only in the 15 subjects given palmvitee during the initial 4 wk. The crossover confirmed these actions of palmvitee. There was a carry over effect of palmvitee. Serum cholesterol concentrations of seven hypercholesterolemic subjects (greater than 7.84 mmol/L) decreased 31% during a 4-wk period in which they were given 200 mg gamma-tocotrienol/d. This indicates that gamma-tocotrienol may be the most potent cholesterol inhibitor in palmvitee capsules. The results of this pilot study are very encouraging.
进行了一项为期8周的双盲交叉研究，以比较富含生育三烯酚的棕榈油（每天200毫克Palmvitee胶囊）与每天300毫克玉米油对高胆固醇血症患者（血清胆固醇6.21 - 8.02毫摩尔/升）血脂的影响。仅在最初4周接受Palmvitee的15名受试者中，血清总胆固醇（-15%）、低密度脂蛋白胆固醇（-8%）、载脂蛋白B（-10%）、血栓素（-25%）、血小板因子4（-16%）和葡萄糖（-12%）的浓度显著降低。交叉试验证实了Palmvitee的这些作用。Palmvitee存在残留效应。7名高胆固醇血症患者（大于7.84毫摩尔/升）在接受每天200毫克γ-生育三烯酚的4周期间，血清胆固醇浓度降低了31%。这表明γ-生育三烯酚可能是Palmvitee胶囊中最有效的胆固醇抑制剂。这项初步研究的结果非常令人鼓舞。
