Saggese G, Bertelloni S, Baroncelli G I, Perri G, Calderazzi A
Department of Pediatrics, University of Pisa, Italy.
Am J Dis Child. 1991 Apr;145(4):457-62. doi: 10.1001/archpedi.1991.02160040119019.
Idiopathic juvenile osteoporosis is a rare cause of osteoporosis during childhood. We examined four children (three boys and one girl, ranging in age from 2.3 to 12.6 years) with idiopathic juvenile osteoporosis. All of these patients had normal serum calcium, ionized calcium, phosphate, magnesium, 25-hydroxyvitamin D, intact parathyroid hormone, and total and extractable calcitonin levels. 1,25-Dihydroxyvitamin D values were low in three patients and slightly decreased in one. Three children were treated with calcitriol (1,25-dihydroxycholecalciferol) (0.50 micrograms/d in two and 0.25 microgram/d in the other). The fourth patient was not treated because of parental refusal. Therapy reduced the fracture rate. Follow-up at 6 and 12 months showed a significant increase in bone mineralization, which reached normal values in two children after 12 months of treatment. No side effects of calcitriol therapy were observed. The untreated patient did not show an improvement of bone mineralization in the same time.
特发性青少年骨质疏松症是儿童期骨质疏松症的罕见病因。我们检查了4例特发性青少年骨质疏松症患儿（3例男孩和1例女孩，年龄在2.3至12.6岁之间）。所有这些患者的血清钙、离子钙、磷酸盐、镁、25-羟基维生素D、完整甲状旁腺激素以及总降钙素和可提取降钙素水平均正常。3例患者的1,25-二羟基维生素D值较低，1例略有下降。3例患儿接受了骨化三醇（1,25-二羟胆钙化醇）治疗（2例每日0.50微克，另1例每日0.25微克）。第四例患者因家长拒绝而未接受治疗。治疗降低了骨折发生率。6个月和12个月的随访显示骨矿化显著增加，2例患儿在治疗12个月后骨矿化达到正常水平。未观察到骨化三醇治疗的副作用。未治疗的患者在同一时期骨矿化未改善。
