Rafiev Kh K, Aliev S P, Karimov S S, Khodzhaeva N M, Bazarova L M
Med Parazitol (Mosk). 2009 Oct-Dec(4):50-4.
The highest malaria morbidity rates have been observed in the Tajikistan's Khatlon Region that is contiguous with Afghanistan. This area is notorious for its high malariogenicity ("susceptibility" according to the WHO terminology), caused by natural climatic factors, as well as a significant vulnerability associated with socioeconomic conditions (intensive migration of populations among which there are many infected subjects). In children, tropical malaria is generally characterized by an acute onset, abnormal fever, and its polymorphism of clinical manifestations that are exemplified by the lack of typical malaria paroxysms, as well as a gradual progression of parasitemia during the first malaria attacks. Recurrences are induced by ineffective treatment and chloroquine resistance in the tropical malaria pathogen. The reduction in malaria morbidity has resulted from a package of large-scale malaria-controlling measures implemented with the support of the Global Fund to Fight AIDS, Tuberculosis, and Malaria.
塔吉克斯坦与阿富汗接壤的哈特隆地区疟疾发病率最高。该地区因自然气候因素导致的高疟原虫感染性（按照世界卫生组织的术语为“易感性”）以及与社会经济状况相关的显著脆弱性（人口大量迁移，其中有许多感染者）而声名狼藉。在儿童中，热带疟疾通常表现为急性发作、发热异常、临床表现具有多态性，如缺乏典型的疟疾发作，以及在首次疟疾发作期间寄生虫血症逐渐加重。复发是由热带疟疾病原体治疗无效和对氯喹耐药引起的。疟疾发病率的下降得益于在抗击艾滋病、结核病和疟疾全球基金支持下实施的一系列大规模疟疾防控措施。
