Talas Zeliha Selamoglu, Bayraktar Nihayet, Ozdemir Ilknur, Gok Yetkin, Yilmaz Ismet
Department of Biology, Faculty of Arts and Science, Nigde University, Nigde-51100, Turkey.
J Environ Biol. 2009 Jul;30(4):591-3.
DMBA (7, 12-dimethylbenz[a]anthracene) is known to generate DNA-reactive species during their metabolism, which may enhance oxidative stress in cells. Since selenium is known as a non-enzymic antioxidant, health problems induced by many environmental pollutants, have stimulated the evaluation of relative antioxidant potential of selenium and synthetic organoselenium compounds. Therefore, we aimed to evaluate chemopreventive potential of synthetic organoselenium compounds by monitoring level of liver nitric oxide. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (Se I) and (Se II) in the determined doses. DMBA-induced in rats, the effects of organoselenium compounds on nitric oxide levels in rat liver was studied. In this study it has been observed a statistically significant increase in (Nitric Oxide) levels for the liver of rat exposed to DMBA (p<0.05). However with administration of Se I and Se II there was a statistically significant decrease in NO levels (p<0.05). The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rat livers was rationalized. Protection against nitric oxide measured in Se I and Se II treated groups were provided by synthesized organoselenium compounds. Se I and Se II both provided chemoprevention against DMBA-induced oxidative stress in rat liver.
已知7,12 - 二甲基苯并[a]蒽（DMBA）在其代谢过程中会产生DNA反应性物质，这可能会增强细胞内的氧化应激。由于硒是一种非酶抗氧化剂，许多环境污染物引发的健康问题促使人们对硒和合成有机硒化合物的相对抗氧化潜力进行评估。因此，我们旨在通过监测肝脏一氧化氮水平来评估合成有机硒化合物的化学预防潜力。在本研究中，成年雌性Wistar大鼠接受了确定剂量的DMBA以及新型有机硒化合物（硒I）和（硒II）的处理。研究了DMBA诱导大鼠后，有机硒化合物对大鼠肝脏一氧化氮水平的影响。在本研究中，观察到暴露于DMBA的大鼠肝脏中（一氧化氮）水平有统计学意义的升高（p<0.05）。然而，给予硒I和硒II后，一氧化氮水平有统计学意义的下降（p<0.05）。有机硒化合物预防DMBA诱导的大鼠肝脏氧化损伤的能力得到了合理的解释。合成有机硒化合物为硒I和硒II处理组中测量的一氧化氮提供了保护。硒I和硒II均对DMBA诱导的大鼠肝脏氧化应激起到了化学预防作用。
