Rysakova M P, Pavlova I V
Zh Vyssh Nerv Deiat Im I P Pavlova. 2009 Nov-Dec;59(6):707-20.
In order to reveal characteristics of functioning of amygdalar neuronal network during unconditioned fear, firing patterns of basal and central nuclear neurons and their interaction were studied during freezing (fear), active unconditioned motor reactions (in the absence of fear) to emotionally significant stimuli, and during quiet wakefulness. As compared to other states, specific changes in interaction of adjacent amygdalar neurons took place during freezing. Such changes were not revealed in firing of single neurons. During freezing, the number of short-latency (to 100 ms) excitatory connections increased and the number of long-latency (250-450 ms) inhibitory connections decreased. In freezing, more frequently than in other states, delta-2 range frequencies (from 2 to 4 Hz) were observed in the interneuronal interaction. During active locomotor reactions to stimuli, the number of interacting neurons decreased, the number of long-latency (200-250 ms) excitatory and short-latency (50-200 ms) inhibitory connections decreased, and theta 1-range frequencies were frequently observed in the interaction. It was concluded that, for the development of fear, the balance between excitatory and inhibitory links of amygdalar neuronal network is essential.
为了揭示杏仁核神经元网络在无条件恐惧期间的功能特征，研究了基底核和中央核神经元在僵住（恐惧）、对情感上重要刺激的主动无条件运动反应（无恐惧）以及安静觉醒期间的放电模式及其相互作用。与其他状态相比，僵住期间杏仁核相邻神经元的相互作用发生了特定变化。在单个神经元的放电中未发现此类变化。在僵住期间，短潜伏期（至100毫秒）兴奋性连接的数量增加，长潜伏期（250 - 450毫秒）抑制性连接的数量减少。在僵住时，神经元间相互作用中比其他状态更频繁地观察到δ2范围频率（2至4赫兹）。在对刺激的主动运动反应期间，相互作用的神经元数量减少，长潜伏期（200 - 250毫秒）兴奋性和短潜伏期（50 - 200毫秒）抑制性连接的数量减少，并且在相互作用中频繁观察到θ1范围频率。得出的结论是，对于恐惧的产生，杏仁核神经元网络兴奋性和抑制性连接之间的平衡至关重要。
