Rysakova M P, Pavlova I V
Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 May-Jun;61(3):351-64.
The influence of systemic injection of anxiolytic afobazole (1 mg/kg) on interaction between neurons of the basal and central amygdaloor nuclei and behavior of rabbits in negative emotional situations was studied in order to reveal characteristics of amygdalar neuronal network properties during unconditioned fear. An afobazole injection results in a prolongation of stay in the light compartment of dark-light chamber, in a decrease in freezing probability after exposure of emotional stimuli, in appearance of some aggressive reactions in open field. Behavioral alterations were accompanied by duration increase and latency changes of amygdalar neuronal inhibitory interactions, by increase of probability of neuronal interactions on delta-range frequency, by decrease of interactions on theta-range frequency. Under the influence of afobazole the asymmetry with right dominance in interhemispheric interaction of amygdalar neurons decreased. Changes in network properties ofamygdalar neurons during afobazole injection testify to reduction of activation level of this structure taking place at the expense of enhancement of inhibitory interactions between neurons.
为揭示无条件恐惧时杏仁核神经元网络特性的特点，研究了全身注射抗焦虑药阿福唑仑（1毫克/千克）对家兔基底杏仁核和中央杏仁核神经元之间相互作用以及在负性情绪情境下行为的影响。注射阿福唑仑会导致家兔在明暗箱的亮区停留时间延长，情绪刺激暴露后僵住概率降低，在旷场中出现一些攻击反应。行为改变伴随着杏仁核神经元抑制性相互作用的持续时间增加和潜伏期变化，δ频段频率的神经元相互作用概率增加，θ频段频率的相互作用减少。在阿福唑仑的影响下，杏仁核神经元半球间相互作用中右侧优势的不对称性降低。注射阿福唑仑期间杏仁核神经元网络特性的变化证明，该结构的激活水平降低，这是以增强神经元之间的抑制性相互作用为代价的。
