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提高对银屑病关节炎的认识。

Improving recognition of psoriatic arthritis.

作者信息

Conaghan Philip G, Coates Laura C

机构信息

Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit.

出版信息

Practitioner. 2009 Dec;253(1724):15-8, 2-3.


DOI:
PMID:20120827
Abstract

Psoriatic arthritis (PsA) is a common form of inflammatory arthritis but is underdiagnosed. Psoriasis affects over 1.5% of the UK population. Around 15% of these patients will be diagnosed with PsA, but up to 40% may have evidence of arthritis if reviewed thoroughly. PsA can be difficult to diagnose as patients present with a variety of different patterns of arthritis. Most patients with PsA have relatively mild skin psoriasis, but some have more significant disease. Only 10-20% develop arthritis before their skin disease. Many patients have mild skin psoriasis that they are unaware of, or have not had diagnosed. Joint involvement is far more variable in PsA, compared with rheumatoid arthritis, and patients may present with: monoarthritis; oligoarthritis; involvement of the distal interphalangeal joints; a rheumatoid arthritis-like picture with multiple joints involved including the small joints in the hand or axial disease producing symptoms similar to ankylosing spondylitis. Features such as dactylitis (uniform sausage-like swelling of the whole digit either finger or toe) and enthesitis (inflammation at the sites of muscle or tendon attachment to bone) may also help diagnose PsA. Skin disease is present in the majority of patients although not all. Hidden areas for psoriasis include: behind the ears; at the top of the natal cleft and around the umbilicus. Larger joints, particularly the knees, can develop very big effusions causing obvious swelling. Areas to test for enthesitis should include the Achilles tendon, plantar fascia, costochondral joints and the elbow. Patients with suspected PsA should be referred promptly to a rheumatologist for further assessment and treatment. Diagnosis of PsA can be made on clinical grounds but blood tests and radiographs are performed routinely to aid diagnosis. Initial therapy for PsA should include NSAIDs to ease pain and stiffness. Local injections of corticosteroids are recommended for peripheral arthritis (given IA) and dactylitis (usually by injection into the flexor tendon or adjacent joints). DMARDs are routinely used to treat all aspects of psoriatic disease, except spinal disease, and prescribing should be initiated by a specialist.

摘要

银屑病关节炎(PsA)是一种常见的炎性关节炎,但常被漏诊。银屑病影响着超过1.5%的英国人口。这些患者中约15%会被诊断为PsA,但如果进行全面检查,高达40%的患者可能有关节炎的证据。PsA可能难以诊断,因为患者表现出各种不同类型的关节炎。大多数PsA患者的皮肤银屑病相对较轻,但有些患者病情较为严重。只有10 - 20%的患者在皮肤疾病出现之前就发展为关节炎。许多患者有轻度的皮肤银屑病,他们自己并未意识到,或者未被诊断出来。与类风湿关节炎相比,PsA的关节受累情况差异更大,患者可能表现为:单关节炎;少关节炎;远端指间关节受累;类似类风湿关节炎的表现,累及多个关节,包括手部小关节,或出现类似强直性脊柱炎症状的中轴疾病。指(趾)炎(整个手指或脚趾呈均匀的腊肠样肿胀)和附着点炎(肌肉或肌腱附着于骨骼部位的炎症)等特征也有助于诊断PsA。大多数患者存在皮肤疾病,但并非所有患者都有。银屑病的隐匿部位包括:耳后;臀裂顶部和脐周。较大的关节,尤其是膝关节,可能会出现非常大的积液,导致明显肿胀。检测附着点炎的部位应包括跟腱、足底筋膜、肋软骨关节和肘部。疑似PsA的患者应及时转诊给风湿病专科医生进行进一步评估和治疗。PsA的诊断可基于临床症状,但通常会进行血液检查和X光检查以辅助诊断。PsA的初始治疗应包括使用非甾体抗炎药来缓解疼痛和僵硬。对于外周关节炎(关节内注射)和指(趾)炎(通常注射到屈肌腱或相邻关节),建议局部注射皮质类固醇。除脊柱疾病外,改善病情抗风湿药通常用于治疗银屑病的各个方面,且应由专科医生开始处方用药。

相似文献

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[2]
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[3]
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[4]
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[5]
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[6]
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