基质金属蛋白酶-9的表达及影响对鼻息肉预后的作用
[The effect of the expression and influence of MMP-9 on prognosis of nasal polyps].
作者信息
Chen Jiangbo, Wang Tiansheng, Sun Hong
机构信息
Department of Otolaryngology, the Third Xiangya Hospital, Central South University, Chan-gsha, 410013, China.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Sep;23(18):840-2, 845.
OBJECTIVE
To study the expression of MMP-9 and eosinophils in nasal polyps and its influence on the prognosis.
METHOD
Study the expression of MMP-9 and EOS on the tissue of nasal polyps of patients who were cured or recurrent and normal nasal mucosa (NM) by immunohistochemistry and HE staining.
RESULT
In the patients of recurrent group (Group B), the expression of MMP-9 was much stronger than that of good prognosis group (Group A) and NM. The MMP-9 was stronger in the eosinophil nasal polyps than that of non-eosinophil groups. The percentage of EOS in Group A was 16.67%, while 62.50% in the Group B.
CONCLUSION
The stronger expression of MMP-9 on Group B and eosinophil group indicated that MMP-9 might affect the prognosis of nasal polyps through inducing the number of EOS in the mucosa. MMP-9 may be one of the risk factors for the relapse of nasal polyps.
目的
研究基质金属蛋白酶-9（MMP-9）和嗜酸性粒细胞在鼻息肉中的表达及其对预后的影响。
方法
采用免疫组织化学和苏木精-伊红（HE）染色法，研究治愈或复发患者鼻息肉组织及正常鼻黏膜（NM）中MMP-9和嗜酸性粒细胞（EOS）的表达。
结果
复发组（B组）患者MMP-9的表达明显强于预后良好组（A组）和正常鼻黏膜。嗜酸性粒细胞性鼻息肉中MMP-9的表达强于非嗜酸性粒细胞组。A组EOS百分比为16.67%，而B组为62.50%。
结论
B组和嗜酸性粒细胞组MMP-9的较强表达表明，MMP-9可能通过诱导黏膜中EOS数量影响鼻息肉的预后。MMP-9可能是鼻息肉复发的危险因素之一。
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